Again, it's the COVID gene injection vaccine, stupid! not virus! Miller et al.: "Substantial Neutralization Escape by the SARS-CoV-2 Omicron Variant BQ.1.1"; 'antigenic sin', BA.2.75.2 & BQ.1.1escape
by Paul Alexander
NAbs induced by infection & vaccination more effective than BA.5. BQ.1.1 NAb titers were lower than BA.5 NAb titers by a factor of 7 in two cohorts who received monovalent or bivalent mRNA boosters
See graphs below, see Wuhan (extreme vertical points on left side of graph), vs BA.5, vs BQ1.1 (extreme right), pre and post boost.
This is Original antigenic sin (OAS) (I have renamed it ‘Mortal antigenic sin or MAS) based on immune fixation, immune priming or imprinting or as some would say, ‘prejudicing’ of the immune response where the recall antibodies and immune response is to the initial prime or exposure, be it vaccine or infection. I have called it MAS because IMO as to how I understand, the immune fixation or recall will always be to the initial prime and so no fixing that. This can result in viral immune escape and antibody-dependent enhancement of infection (ADEI).
Here researchers found that BQ.1.1 NAb (neutralizing antibodies) titers were lower than BA.5 which is the predominant sub-variant clade circulating, though BA.5 is likely to be replaced soon by other variants.
Again, we warn that it is the mRNA antigenic-specific, high-affinity, vaccinal antibodies that are binding to the virus spike antigen yet not neutralizing the virus (stopping infection or replication or transmission and actually enhancing replication) and driving the natural selection of more infectious sub-variants. When you vaccinate (roll out a vaccine) across all age groups into a pandemic with ongoing elevated infectious pressure and using a non-sterilizing, non-neutralizing vaccine, then selection pressure will drive selection and emergence of more ‘fitter’ variants and some (one) can even be ‘hotter’ (more virulent in terms of causing severity of illness). CVB warns openly about this and IMO, this is a smart scientist, learned, pay attention to him.
‘Omicron BA.5 has been the globally dominant SARS-CoV-2 variant and has demonstrated substantial neutralization escape compared with prior variants. Additional Omicron variants have recently emerged, including BA.4.6, BF.7, BA.2.75.2, and BQ.1.1, all of which have the Spike R346T mutation. In particular, BQ.1.1 has rapidly increased in frequency, and BA.5 has recently declined to less than half of viruses in the United States.
Our data demonstrate that BA.2.75.2 and BQ.1.1 escape NAbs induced by infection and vaccination more effectively than BA.5. BQ.1.1 NAb titers were lower than BA.5 NAb titers by a factor of 7 in two cohorts of individuals who received the monovalent or bivalent mRNA vaccine boosters. These findings provide the immunologic context for the rapid increase in BQ.1.1 prevalence in regions where BA.5 is dominant and have implications for both vaccine immunity and natural immunity.’ (see graphs B, C and D below).