Barberis et al.: "Circulating Exosomes Are Strongly Involved in SARS-CoV-2 Infection"; argument is that exosomes & extra-cellular vehicles packed with spike protein & microRNAs also due to COVID jab

by Paul Alexander

During the course of a viral infection, host cells release exosomes and other extracellular vesicles carrying viral and host components (mRNA + spike) that can modulate the immune response.

SOURCE:

https://pubmed.ncbi.nlm.nih.gov/33693030/

 

‘Knowledge of the host response to the novel coronavirus SARS-CoV-2 remains limited, hindering the understanding of COVID-19 pathogenesis and the development of therapeutic strategies.

During the course of a viral infection, host cells release exosomes and other extracellular vesicles carrying viral and host components that can modulate the immune response. (Note, these viral components include the spike protein and microRNAs etc. The key argument is that whatever the virus does, the vaccine can do and worse).

‘The present study used a shotgun proteomic approach to map the host circulating exosomes' response to SARS-CoV-2 infection. We investigated how SARS-CoV-2 infection modulates exosome content, exosomes' involvement in disease progression, and the potential use of plasma exosomes as biomarkers of disease severity.

A proteomic analysis of patient-derived exosomes identified several molecules involved in the immune response, inflammation, and activation of the coagulation and complement pathways, which are the main mechanisms of COVID-19-associated tissue damage and multiple organ dysfunctions.’

‘In addition, several potential biomarkers-such as fibrinogen, fibronectin, complement C1r subcomponent and serum amyloid P-component-were shown to have a diagnostic feature presenting an area under the curve (AUC) of almost 1. Proteins correlating with disease severity were also detected. '

‘Moreover, for the first time, we identified the presence of SARS-CoV-2 RNA in the exosomal cargo, which suggests that the virus might use the endocytosis route to spread infection. Our findings indicate circulating exosomes' significant contribution to several processes-such as inflammation, coagulation, and immunomodulation-during SARS-CoV-2 infection.’