Boettler et al: HEPATITIS post COVID shot: "highly activated T cells accumulate and are evenly distributed in the different areas of the liver with liver inflammation following SARS-CoV-2 vaccination"

An important hepatitis flag signal study we wish to keep you informed of for your decision-making

“Conclusions: COVID-19 vaccination can elicit a distinct T cell-dominant immune-mediated hepatitis with a unique patho-mechanism associated with vaccination-induced antigen-specific tissue-resident immunity requiring systemic immunosuppression.

Lay summary: Liver inflammation is observed during SARS-CoV-2 infection but can also occur in some individuals after vaccination and shares some typical features with autoimmune liver disease. In this report, we show that highly activated T cells accumulate and are evenly distributed in the different areas of the liver in a patient with liver inflammation following SARS-CoV-2 vaccination. Moreover, within the population of these liver-infiltrating T cells, we observed an enrichment of T cells that are reactive to SARS-CoV-2, suggesting that these vaccine-induced cells can contribute to liver inflammation in this context.”

SOURCE:

Boettler et al.: SARS-CoV-2 vaccination can elicit a CD8 T-cell dominant hepatitis