BREAKING study: Yonker et al.: "Circulating Spike Protein Detected in Post–COVID-19 mRNA Vaccine Myocarditis"; 'notable find was that markedly elevated levels of full-length spike protein (33.9±22.4 pg/mL)
by Paul Alexander
unbound by antibodies, detected in the plasma of individuals with postvaccine myocarditis while no free spike detected in asymptomatic vaccinated control subjects (unpaired t test P<0.0001)"
Could the vaccine-induced myocarditis be due to the free ‘unbound’ spike protein? This study en face, seems to be suggesting that it is the spike protein that may be the toxic culprit. But you already know this, as we have been saying this and documenting it 2 years now that the spike protein is an endothelial pathogen, devastating on the inner endothelial layer walls of the vasculature.
‘We discovered that individuals who developed postvaccine myocarditis uniquely exhibit elevated levels of free spike protein in circulation, unbound by anti-spike antibodies, which appear to correlate with cardiac troponin T levels and innate immune activation with cytokine release.
However, adaptive immunity and T-cell responses were essentially indistinguishable from those of asymptomatic age-matched vaccinated control subjects. The postvaccine myocarditis immuno-profile is distinct, however, from acute SARS-CoV-2 infection and the delayed post-inflammatory illness MIS-C.’
‘From January 2021 through February 2022, prospectively collected blood from 16 patients who were hospitalized at Massachusetts General for Children or Boston Children’s Hospital for myocarditis, presenting with chest pain with elevated cardiac troponin T after SARS-CoV-2 vaccination…performed extensive antibody profiling, including tests for SARS-CoV-2–specific humoral responses and assessment for autoantibodies or antibodies against the human-relevant virome, SARS-CoV-2–specific T-cell analysis, and cytokine and SARS-CoV-2 antigen profiling. Results were compared with those from 45 healthy, asymptomatic, age-matched vaccinated control subjects.
Extensive antibody profiling and T-cell responses in the individuals who developed postvaccine myocarditis were essentially indistinguishable from those of vaccinated control subjects, despite a modest increase in cytokine production.
Sixty-one adolescents and young adults between 12 and 21 years of age, including 16 individuals with vaccine-as-sociated myocarditis, provided a blood sample for analysis.
A notable finding was that markedly elevated levels of full-length spike protein (33.9±22.4 pg/mL), unbound by antibodies, were detected in the plasma of individuals with postvaccine myocarditis, whereas no free spike was detected in asymptomatic vaccinated control subjects (unpaired t test; P<0.0001). see Figure 4A.
However, free spike antigen was detected in the blood of adolescents and young adults who developed post-mRNA vaccine myocarditis, advancing insight into its potential underlying cause.’
Immuno-profiling of vaccinated adolescents and young adults revealed that the mRNA vaccine–induced immune responses did not differ between individuals who developed myocarditis and individuals who did not.
Although postvaccine myocarditis clinically occurs more commonly in males, elevated spike was seen equally in both affected females and males (Figure S5).
‘The persistence of circulating spike in patients with postvaccine myocarditis is similar to the SARS-CoV-2 antigenemia previously reported to be a pathogenic feature of MIS-C.18,21 For that reason, we compared S1, spike, cardiac troponin T, and CRP levels between individuals who developed myocarditis and those who developed MIS-C with cardiac complications (Figure 5). There were no significant differences in the mean S1 and spike concentrations between the 2 groups.’