Cao et al.: "Imprinted SARS-CoV-2 humoral immunity induces convergent Omicron RBD evolution"; suggests that current herd immunity & BA.5 vaccine boosters may not provide sufficiently broad protection
by Paul Alexander
We have said months now the bivalent booster WILL fail and will not work well: original antigenic sin (hidden antigenic sin), antibody-dependent enhancement of infection & disease, viral immune escape
Once again, a rapid mass vaccination campaign that utilizes a sub-optimal antigen-specific non-neutralizing vaccine (such as the COVID vaccines) and with vaccination across all age groups, and into the pandemic as we did and continue to do (in the midst of an active pandemic of a highly mutable and highly infectious respiratory virus e.g. omicron BA.5 sub-variant clade with high ‘circulating’ infectious pressure) can only generate a continued series of dominating new variants that are increasingly infectious, increasingly vaccine-resistant (due to “immune escape”), and inevitably more virulent (potentially lethal). In short, the mass vaccination campaign that has been implemented during the COVID pandemic (and continues now with the bivalent booster (Wuhan spike + BA.4 and BA.5 spike)) can potentially keep the pandemic going for many years with a potential more virulent sub-variant emerging.
I am saying this pandemic will last 100 more years once we keep vaccinating the way we are and using the same non-neutralizing non-sterilizing vaccines that do not eliminate the virus and stop transmission. Fauci, Bourla, Bancel, and Francis Collins know exactly what they are doing here. This is deliberate. They cannot be that stupid.