Common colds are coronaviruses and children's prior exposure cross-protects/cross-reacts with SARS-CoV-2/COVID; explains why at such LOW risk; Dowell et al. (NATURE study); must NOT get vaccinated
by Paul Alexander
Explains why children have been largely spared from COVID…also explains that the term ‘novel coronavirus’ was duplicitous as there was nothing novel about this, we had prior exposure and cross-protection from common colds.
So what does this study indicate?
Well, it gives us further evidence (Dowell et al.) on why children MUST NOT be given these COVID vaccines and why POTUS Trump is wrong to champion them given the devastating efficacy/effectiveness (failure on Delta and Omicron) and the CDC's VAERS database reported harms and deaths from the vaccine; he is wrong! CANDACE Owens must not try to explain away Trump’s incorrect answers. I support him but he is flat wrong on the vaccines. He has not waged the fight to indicate that children are not candidates for these vaccines and this is terrible given the potential risks and the fact that the vaccines were not studied for the proper duration of time. We thus have no clear assessment of safety on which to judge. Importantly, children simply do not need the vaccines. We know that children have 4-5 common colds per year and the Dowell research highlights what we understood as to a level of immunity conferred by prior common colds. Existing and it protects.
Dowell et al. show children mount extraordinary ‘enhanced’ immune responses relative to adults, with pre-existing immunity cross-reactive/cross-protective with pre-pandemic ‘common cold’ coronaviruses (as a result of prior exposure) as well as SARS-CoV-2.
The biological age of an individual is the primary risk factor associated with the clinical severity of SARS-CoV-2 infection. Although comorbidities (for example, cardiovascular disease and obesity) accumulate with age and thereby increase the chances of severe illness or fatal disease, they cannot explain why increasing age is an independent risk factor, or why, notably, SARS-CoV-2 infection tends to be mild or even asymptomatic in children and young adults.
The importance of age as a risk factor is underscored by early estimates in 2020 that adults >65 years in age represented 80% of hospitalizations and had a 23-fold greater risk of death than those <65 years of age. This trend has been maintained throughout the pandemic, and according to recent calculations, almost 76% of ~737,000 cumulative deaths in the United States (as of 27 October 2021) were of individuals aged ≥65 years. Notably, the hospitalization or death rate in this age range is approximately 1,000–8,000 times higher than in the 0–17-year old reference group. In one landmark analysis, the infection fatality ratio was calculated to be the lowest among children (aged 5–9 years)
Although SARS-CoV-2 is a new coronavirus circulating within the human population, the majority of people throughout their lives have been exposed to antigenically related seasonal endemic HCoVs (human CoVs) and have detectable HCoV-specific humoral, B cell and T cell immune responses.
It is increasingly clear that CD4+ T cells, CD8+ T cells and antibodies (neutralizing and non-neutralizing) all contribute to the collective control of SARS-CoV-2 infection and disease.
They found that “Spike-specific T cell responses were more than twice as high in children and were also detected in many seronegative children, indicating pre-existing cross-reactive responses to seasonal coronaviruses.” Dowell et al. go on to show that “the durability of the polyclonal spike-specific humoral immune response in children is robust ≥12 months after infection, and is quantitively superior to antibody responses in adults. For example, compared with adults, children maintain higher levels of antibody binding to the Wuhan SARS-CoV-2 founder virus and to a broader panel of variants of concern (VOC). Although children have better antibody binding to VOC spike proteins, virus-neutralizing capacity is nevertheless equivalent in adults and children. Of note, children have superior retention (>6 months) of antibodies that bind to non-neutralizing spike epitopes. However, whether these non-neutralizing antibodies provide protection through Fc-mediated functions is unclear. In summary, these data from Dowell and colleagues illustrate how children — after natural infection — develop durable titers of polyclonal plasma antibodies that have superior binding to SARS-CoV-2 VOC, but are endowed with similar neutralizing potency when compared with the adult antibody response.” (https://www.nature.com/articles/s41590-021-01094-x; https://www.nature.com/articles/s41590-021-01094-x).