Dementia & Vitamin D supplementation: vitamin D supplementation and incident dementia: Effects of sex, APOE, and baseline cognitive status (Ghahremani et al.); Across all formulations, vitamin D

by Paul Alexander

exposure was associated with significantly longer dementia-free survival and lower dementia incidence rate than no exposure (hazard ratio = 0.60, 95% confidence interval: 0.55-0.65)

‘In a prospective cohort study, we assessed effects of Vitamin D on dementia incidence in 12,388 participants from the National Alzheimer's Coordinating Center dataset. Vitamin D exposure was associated with 40% lower dementia incidence versus no exposure. Vitamin D effects were significantly greater in females versus males and in normal cognition versus mild cognitive impairment. Vitamin D effects were significantly greater in apolipoprotein E ε4 non-carriers versus carriers. Vitamin D has potential for dementia prevention, especially in the high-risk strata.’