Did Fleming-Dutra et al. (JAMA) show via a test-negative, case-control study (same design LADAPO uses yet gets pilloried for) that vaccine effectiveness plunges (to negative effectiveness) in children
by Paul Alexander
& adolescents? Yes, certainly did! CDC, Pfizer etc. did not comment on this key study; why? 47,700 tests among 5-11 & 12- to 15-year-olds
‘In a test-negative, case-control study conducted from December 2021 to February 2022 during Omicron variant predominance that included 121 952 tests from sites across the US, estimated vaccine effectiveness against symptomatic infection for children 5 to 11 years of age was 60.1% 2 to 4 weeks after dose 2 and 28.9% during month 2 after dose 2. Among adolescents 12 to 15 years of age, estimated vaccine effectiveness was 59.5% 2 to 4 weeks after dose 2 and 16.6% during month 2’.
‘found the estimated VE of the BNT162b2 2-dose primary series against symptomatic infection with the Omicron variant was modest and decreased over time since vaccination in both age groups, similar to the pattern observed in adults during Omicron variant predominance.’