Dowell et al.: "Children develop robust and sustained cross-reactive spike-specific immune responses to SARS-CoV-2 infection"; children retained antibody & cellular responses, as it waned in adults
by Paul Alexander
Key finding: Children generate robust, cross-reactive and sustained immune responses to SARS-CoV-2 with focused specificity for the spike protein.
This important study has been overlooked and sidelined for the findings do not fit the narrative. It is one additional win for natural immunity. Helps us understand why children, healthy children must not be touched with these COVID injections. They do not need them but importantly, the injection can damage their functional innate immune system and render it helpless and children then vulnerable to a broad range of pathogen.
“SARS-CoV-2 infection is generally mild or asymptomatic in children but a biological basis for this outcome is unclear. Here we compare antibody and cellular immunity in children (aged 3–11 years) and adults. Antibody responses against spike protein were high in children and seroconversion boosted responses against seasonal Beta-coronaviruses through cross-recognition of the S2 domain. Neutralization of viral variants was comparable between children and adults. Spike-specific T cell responses were more than twice as high in children and were also detected in many seronegative children, indicating pre-existing cross-reactive responses to seasonal coronaviruses. Importantly, children retained antibody and cellular responses 6 months after infection, whereas relative waning occurred in adults. Spike-specific responses were also broadly stable beyond 12 months. Therefore, children generate robust, cross-reactive and sustained immune responses to SARS-CoV-2 with focused specificity for the spike protein. These findings provide insight into the relative clinical protection that occurs in most children and might help to guide the design of pediatric vaccination regimens.”