Fantini et al. & Liu et al., 2 key COVID mRNA gene injection studies show original antigenic sin & antibody-dependent enhancement of infection, shows that mRNA vaccine makes virus more infectious

by Paul Alexander

Fantini: stabilizing mechanism may facilitate the conformational change that induces the demasking of receptor binding domain; Liu: enhanced the binding capacity of spike protein to ACE2 & infectivity

Fantini et al:

SOURCE:

 

https://pubmed.ncbi.nlm.nih.gov/34384810/

Key statement:

‘Since the Covid-19 pandemic is now dominated with Delta variants, we analyzed the interaction of facilitating antibodies with the NTD of these variants. Using molecular modeling approaches, we show that enhancing antibodies have a higher affinity for Delta variants than for Wuhan/D614G NTDs. We show that enhancing antibodies reinforce the binding of the spike trimer to the host cell membrane by clamping the NTD to lipid raft microdomains. This stabilizing mechanism may facilitate the conformational change that induces the demasking of the receptor binding domain…However, in the case of the Delta variant, neutralizing antibodies have a decreased affinity for the spike protein, whereas facilitating antibodies display a strikingly increased affinity. Thus, ADE may be a concern for people receiving vaccines based on the original Wuhan strain spike sequence (either mRNA or viral vectors).’

Liu et al:

SOURCE:

https://www.sciencedirect.com/science/article/pii/S0092867421006620

Key statement:

‘The open RBD state is induced upon antibody binding to a specific site on the NTD…screened a series of anti-spike monoclonal antibodies from coronavirus disease 2019 (COVID-19) patients and found that some of antibodies against the N-terminal domain (NTD) induced the open conformation of RBD and thus enhanced the binding capacity of the spike protein to ACE2 and infectivity of SARS-CoV-2.’

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