Frequent COVID-19 booster shots could adversely affect (decrease) the immune response and can be caused by several factors such as N1-methylpseudouridine, the spike protein, lipid nanoparticles,
by Paul Alexander
antibody-dependent enhancement, and the original antigenic stimulus.
SOURCE:
https://pubmed.ncbi.nlm.nih.gov/35659687/
As a safety measure, further booster vaccinations should be discontinued. In addition, the date of vaccination should be recorded in the medical record of patients. Several practical measures to prevent a decrease in immunity have been reported. These include limiting the use of non-steroidal anti-inflammatory drugs, including acetaminophen to maintain deep body temperature, appropriate use of antibiotics, smoking cessation, stress control, and limiting the use of lipid emulsions, including propofol, which may cause perioperative immunosuppression. In conclusion, COVID-19 vaccination is a major risk factor for infections in critically ill patients.’