IgG4 'class switch' (Irrgang et al.) toward noninflammatory, spike-specific IgG4 antibodies after repeated COVID mRNA vaccination; a problem for mRNA technology based gene injected vaccinees? YES!

by Paul Alexander

immunoglobulin G (IgG) response mainly consists of proinflammatory subclasses IgG1 & IgG3; but several months post second vaccination, antibodies mainly IgG4 boosted by 3rd shot (rose 0.04% to 19.3%)


‘High levels of neutralizing SARS-CoV-2 antibodies are an important component of vaccine-induced immunity. Shortly after the initial two mRNA vaccine doses, the immunoglobulin G (IgG) response mainly consists of the proinflammatory subclasses IgG1 and IgG3. Here, we report that several months after the second vaccination, SARS-CoV-2-specific antibodies were increasingly composed of noninflammatory IgG4, which were further boosted by a third mRNA vaccination and/or SARS-CoV-2 variant breakthrough infections. IgG4 antibodies among all spike-specific IgG antibodies rose, on average, from 0.04% shortly after the second vaccination to 19.27% late after the third vaccination.’

This induction of IgG4 antibodies was not observed after homologous or heterologous SARS-CoV-2 vaccination with adenoviral vectors.

This class switch was associated with a reduced capacity of the spike-specific antibodies to mediate antibody-dependent cellular phagocytosis and complement deposition.’