"Immune boosting by B.1.1.529 (Omicron) depends on previous SARS-CoV-2 exposure": immune imprinting from prior Wuhan Hu-1 infection resulted in absence of a T cell response against B.1.1.529 (Omicron)
by Paul Alexander
Johns Hopkins epidemiologist Dr. Marty Makary raises the issue of immune imprinting from multiple booster doses weakening the immune system; initial legacy Wuhan antibodies recalled
Key statements:
‘HCWs with a previous history of SARS-CoV-2 infection during the Wuhan Hu-1 wave responded to B.1.1.529 (Omicron) S1 protein (Fig. 5A). This suggests that, in this context, B.1.1.529 (Omicron) infection was unable to boost T cell immunity against B.1.1.529 (Omicron) itself; immune imprinting from prior Wuhan Hu-1 infection resulted in the absence of a T cell response against B.1.1.529 (Omicron) S1 protein.’
B-cell response:
