Japanese evidence of immune system thyroid dysfunction by Pfizer COVID injection (disruption of thyroid autoimmunity) with increased thyroid auto-antibodies after 2 doses of Pfizer jab plus booster

by Paul Alexander

2 doses jab with Pfizer plus booster is causing thyroid problems, thyroid dysfunction, thyroid diseases (Morita and Mastuoka); thyroid antibodies increased post 2 doses & still elevated at 32 weeks

Researchers present a ‘twelve-month clinical follow-up of thyroid-stimulating hormone (TSH) receptor antibody (TRAb) as a marker of thyroid autoimmunity disease, GD, and thyroid function from the baseline to after the third dose of the SARS-CoV-2 BNT162b2 (Pfizer/BioNTech) mRNA vaccine in Japanese healthcare workers.’

These results suggest that COVID mRNA vaccine significantly impact thyroid function.


‘In this twelve-month follow-up study in a cohort of Japanese healthcare workers, we showed the first evidence of the SARS-CoV-2 BNT162b2 vaccine increasing TRAb, as a maker of thyroid autoimmunity. In addition, we presented candidate predictive factors to increase TRAb by the vaccine: female sex, baseline low FT4 and FT3. Furthermore, as confirmation of the disruption of the thyroid autoimmunity by the vaccine, we demonstrated that the third dose of mRNA vaccine increased TgAb in 4 weeks.’

See left graph and specifically see Baseline and 4 weeks post 3rd dose:




Serum samples collected from seventy Japanese healthcare workers at baseline, 32 weeks after the second dose (pre-third dose), and 4 weeks after the third dose of the vaccine were analyzed. The time courses of anti-SARS-CoV-2 spike immunoglobulin G (IgG) antibody, thyroid-stimulating hormone receptor antibody (TRAb), and thyroid function were evaluated. Anti-thyroglobulin antibodies (TgAb) and anti-thyroid peroxidase antibodies (TPOAb) were additionally evaluated in thirty-three participants.


The median age was 50 (IQR, 38-54) years and 69% were female. The median anti-spike IgG antibody titer was 17627 (IQR, 10898-24175) U/mL 4 weeks after the third dose. The mean TRAb was significantly increased from 0.81 (SD, 0.05) IU/L at baseline to 0.97 (SD, 0.30) IU/L 4 weeks after the third dose without functional changes. An increase in TRAb was positively associated with female sex (β = 0.32, P = 0.008) and low basal FT4 (β = -0.29, P = 0.02) and FT3 (β = -0.33, P = 0.004). TgAb was increased by the third dose. Increase in TgAb was associated with history of the thyroid diseases (β = 0.55, P <0.001).


SARS-CoV-2 BNT162b2 mRNA vaccine can disrupt thyroid autoimmunity. Clinicians should consider the possibility that the SARS-CoV-2 vaccine may disrupt thyroid autoimmunity.’


Examples of ADDITIONAL research showing COVID mRNA shot impacts thyroid function: