John Ioannidis: 90% of Medical Research Is Wrong; even the Cochrane Collaboration, set up to fix the fraud, turns out to be flawed and corrupted too; 'Why Most Clinical Research Is Not Useful'
by Paul Alexander
Of 49 articles, 45 claimed to have uncovered effective interventions. 34 of these claims had been retested, and 14 of these (41 %), had been convincingly shown to be wrong or significantly exaggerated
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1)Why most published research findings are false
2)A Researcher’s Claim: 90% of Medical Research Is Wrong
‘[Ioannidis] zoomed in on 49 of the most highly regarded research findings in medicine over the previous 13 years, as judged by the science community’s two standard measures: the papers had appeared in the journals most widely cited in research articles, and the 49 articles themselves were the most widely cited articles in these journals. These were articles that helped lead to the widespread popularity of treatments such as the use of hormone-replacement therapy for menopausal women, vitamin E to reduce the risk of heart disease, coronary stents to ward off heart attacks, and daily low-dose aspirin to control blood pressure and prevent heart attacks and strokes.
Ioannidis was putting his contentions to the test not against run-of-the-mill research, or even merely well-accepted research, but against the absolute tip of the research pyramid. Of the 49 articles, 45 claimed to have uncovered effective interventions. Thirty-four of these claims had been retested, and 14 of these, or 41 percent, had been convincingly shown to be wrong or significantly exaggerated. If between a third and a half of the most acclaimed research in medicine was proving untrustworthy, the scope and impact of the problem were undeniable. That article was published in the Journal of the American Medical Association.’
3)Why Most Clinical Research Is Not Useful