Lumbrokinase vs Nattokinase vs Serrapeptase: Blood thinners!! Used to address blood clot prevention (dissolves clots), inflammation reduction, manages the progression of artherosclerosis,

& blood circulation; Thrombolytic agents typically used to dissolve clots are urokinase (u-PA), streptokinase, and tissue plasminogen activator (t-PA).

In a study comparing lumbrokinase to Serrapeptidase, aka serrapeptase, and nattokinase on a milligram to milligram basis, researchers found that lumbrokinase is about 300 times (1/294) stronger than serrapeptase and 30 times (1/36) times stronger than nattokinase. (R)’

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‘Lumbrokinase vs Nattokinase vs Serrapeptase: What's the Difference?

By Meillya Wijaya - June 15, 2023

Lumbrokinase, nattokinase, and serrapeptase are all enzymes that have been studied for their potential health benefits. They are all considered as proteolytic enzymes. Proteolytic enzymes have a variety of roles in the body, from helping to digest food to taking part in the immune response.

What is Lumbrokinase?

Lumbrokinase (LK) is an enzyme derived from earthworms is thought to aid in blood clot prevention, inflammation reduction, and circulation problems. 

Lumbrokinase for Blood Clots

Thrombolytic agents typically used to dissolve clots are urokinase (u-PA), streptokinase, and tissue plasminogen activator (t-PA). These drugs, however, are not specific for fibrin and have adverse and dangerous side effects including severe bleeding and heavy blood loss which may result in death. In contrast, LK is very specific to fibrin as a substrate and it does not cause excessive bleeding. It can dissolve the fibrin itself or convert plasminogen to plasmin by inducing endogenous t-PA activity to dissolve fibrin clots (Source)

Interestingly, for more than ten years, clinical trials have also used lumbrokinase as an oral supplement to support and maintain healthy cardiovascular function as well as to treat cardiovascular diseases.

According to some studies, post-ischemic treatment with lumbrokinase attenuates myocardial I-R injury through the activation of Sirt1 signaling, and thus enhances autophagic flux and reduces I-R-induced oxidative damage, inflammation and apoptosis.

As of June 2023, a simple PubMed keyword search of "lumbrokinase" generated 89 results, with papers dating as far back as 1991. However, performing the same keyword search in one of the largest Chinese digital periodicals database (www.cnki.net) generated over 650 publications! 

What is Nattokinase?

Nattokinase (NK) is an enzyme derived from a traditional Japanese food called natto, and it is thought to help lower cholesterol, reduce inflammation, and improve circulation. 

Nattokinase for Blood Clots

Nattokinase dissolves blood clots by directly hydrolyzing fibrin and plasmin substrate. It converts endogenous prourokinase to urokinase (uPA). It also degrades plasminogen activator inhibitor (PAI-1) and increases the level of tissue plasminogen activator (t-PA). (Source)

Furthermore, a study has also suggests that daily NK supplementation is an effective way to manage the progression of atherosclerosis and potentially may be a better alternative to statins which are commonly used to reduce atherosclerosis and further to prevent cardiovascular attack and stroke in patients.

In this clinical study (Chen 2022) involving 1,062 participants, the objective was to examine the efficacy of NK (nattokinase) in atherosclerosis and hyperlipidemia and safety at the dose of 10,800 FU/day after 12 months of oral administration. 

Authors found that NK at a dose of 10,800 FU/day effectively managed the progression of atherosclerosis and hyperlipidemia with a significant improvement in the lipid profile. The lipid-lowering effect of NK was more prominent in subjects who smoked, drank alcohol, and subjects with higher BMI. Regular exercise further improved the effects of NK. 

Co-administration of vitamin K2 and aspirin with NK produced a synergetic effect. In conclusion, the data demonstrate that atherosclerosis progression and hyperlipidemia can be effectively managed with NK at a dose of 10,800 FU/day. The lower dose of 3,600 FU per day is ineffective. Some lifestyle factors and the coadministration of vitamin K2 and aspirin lead to improved outcomes in the use of NK. The findings provide clinical evidence on the effective dose of NK in the management of cardiovascular disease and challenge the recommended dose of 2,000 FU per day.

Tanikawa et al. (2022) examined the effect of nattokinase on the COVID-19 spike protein. In the first experiment, they demonstrated that spike was degraded in a time and dose-dependent manner in a cell lysate preparation that could be similar to a vaccine recipient. The second experiment demonstrated that nattokinase degraded the spike protein in SARS-CoV-2 infected cells. This was reproduced in a similar study done by Oba and colleagues in 2021.

Related: Holy Grail of COVID-19 Spike Protein Detoxification

What is Serrapeptase?

Serrapeptase is an enzyme derived from silkworms and is thought to lessen pain, thin the blood, and reduce inflammation. Although more research is required to pinpoint their precise effects, all three enzymes may have potential health advantages.

Serrapeptase for Blood Clots

Serratiopeptidase is known to dissolve blood clots and artherosclerotic plaques by breaking down fibrin and other dead or damaged tissue. It can also remove deposits of fatty substances, cholesterol, and cellular waste inside the arteries. The fibrinolytic property of serratiopeptidase may also help with the problems of thick blood, risk of stroke, and thrombophlebitis. (Source)

Lumbrokinase vs Nattokinase vs Serrapeptase

Lumberkinase is good for angina, diabetes, heart disease, lyme disease, stroke prevention, DVT prevention. Lumberkinase can promotes both fibrolysis and fibronogenesis so it can both break down or build up fibrin, depending on the body’s needs. 

In a study comparing lumbrokinase to Serrapeptidase, aka serrapeptase, and nattokinase on a milligram to milligram basis, researchers found that lumbrokinase is about 300 times (1/294) stronger than serrapeptase and 30 times (1/36) times stronger than nattokinase. (R)

Nattokinase is good for atherosclerosis (add magnesium), vascular health, stroke prevention, clot prevention. Interestingly, Nattokinasi is also contain high amounts of vitamin K2. K2 helps to pull the calcium where it shouldn’t be and into the bone where it should be. Low amount of K2 cause calcium to build up in the arteries.

Serrapeptase is good for healthy anti-inflammatory response. It induces fibrolynic anti inflammatory and anti-edemic activity to tissues. This helps desire dissolve scar tissue inflammation like uterine fibroids, blocked fallopian tubes. They are superior for anti inflammatory effects because they have ability to dissolve the fibrous and or scar tissue due to inflammation.’