MADMEN, real MADMEN, why would they create a chimeric SARS-CoV-2 virus with 80% mortality? BIOWEAPON? Chen et al.: "Role of spike in the pathogenic & antigenic behavior of SARS-CoV-2 BA.1 2 Omicron"
by Paul Alexander
"We generated chimeric recombinant SARS-CoV-2 encoding the S gene of Omicron in the backbone of an ancestral SARS-CoV-2 isolate and compared this virus with the naturally circulating Omicron variant.
This Chen et al. paper is a pre-print, not yet peer reviewed, breaking abstract.
Based on this pre-print by Chen et al., we are looking potentially at a chimera that could wipe out humanity. It is that serious for this was the same insanity we saw when Menachery and Baric et al. posted (see embedded url for the 2015 paper below) their 2015 paper telling us the insanity of what they just did in vitro and in vivo creating the gain-of-function very lethal and infectious chimera. “On the basis of these findings, we synthetically re-derived an infectious full-length SHC014 recombinant virus and demonstrate robust viral replication both in vitro and in vivo. Our work suggests a potential risk of SARS-CoV re-emergence from viruses currently circulating in bat populations.”
Menachery and Baric et al. in 2015 told us they just created the very situation we faced with COVID virus, in 2015 and they did not stop. They went stir crazy raving mad in 2015 and beyond, inserting furin cleavage sites (a 9 amino acid genetic sequence just in-between the junction of the S1 and S2 subunits of the spike glycoprotein) into any and every bat coronavirus and chimera they could produce, stitching together parts of coronaviruses or whole viruses to see the ‘spillover’, zoonotic jump from animal to human, to test how infectious and lethal they could make the spike. They did and it seems there are more MADMEN around like these in Boston. The real question is why develop this hybrid strain? What is the value added of this? What purpose does this serve? I see none.
This is Gain-of-Function (GoF) with enhanced pandemic possibilities and so it is technically illegal. I say it is illegal. This is very dangerous virus manipulation research and in a city or location near or in Boston? They should be barred from this work as it can get out and ravage societies. Who funded this insanity? We cannot even deal with what has happened globally with Wuhan legacy strain and we know that the Wuhan Institute of Virology (WIV) with EcoHealth Alliance (Daszak) and University of North Carolina (Chapel Hill) (Baric) were conducting the very same GoF research and we know the result. I just do not get this insanity they have with fooling around with the coronavirus and is it ‘just because I could’?
Menachery and Baric et al. 2015: A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence
Now on to Chen et al.’s stunning breaking 2022 pre-print.
Based on this, we have to ask who is funding this (this is not disclosed) and we can now argue they do not want this to end. This pandemic and this death spiral will continue forever. This pandemic will never end and I will argue with anyone, this was deliberate. Day one! This was a bioweapon. At this rate, this will not end. We have an infectious sub-variant clade BA.5 with a near zero mortality and now these madmen create 80% mortality? I want to know why?
Let us read slowly what they wrote and try to digest it. Note, they stitched together in gain-of-function, present omicron and initial Wuhan legacy strain. Note, present omicron has a lethality of near 0% and if we accept Ioannidis IFR of 0.05% in those < 70 years or 0.15% across the board. So begin wrapping your head around 80% mortality.
Consider this statement:
“We generated chimeric recombinant SARS-CoV-2 encoding the S gene of Omicron in the backbone of an ancestral SARS-CoV-2 isolate and compared this virus with the naturally circulating Omicron variant.”
So these psychos again stitched together parts of other coronaviruses (OMICRON today and Wuhan legacy that is long gone, parts of or complete viruses) and created a new potentially deadly, way more deadly variant. The question is why? Is anyone policing these crazy idiots? Is this bioweaponary?
What about this statement?
“The Omicron S-bearing virus robustly escapes vaccine-induced humoral immunity, mainly due to mutations in the receptor binding motif (RBM), yet unlike naturally occurring Omicron, efficiently replicates in cell lines and primary-like distal lung cells.”
This is very serious if you re-read this, for at present, we have omicron that is largely resistant to the vaccinal non-neutralizing induced antibodies that enhance (facilitate) infectiousness in the upper respiratory tract (facilitate it) yet blocks severe illness (virulence, lethality) in the lower respiratory tract. I assume they meant this by the term ‘distal lung cells’. So have they created a chimera that does not even need to overcome the sub-optimal immune pressure on viral virulence (as Geert Vanden Bossche and myself and others have been warning about), and it can do it NOW? This is potentially catastrophic with an 80% mortality, while omicron still has a near zero mortality??? Why did these people do this?
Consider this statement now:
“In K18-hACE2 mice, while Omicron causes mild, non-fatal infection, the Omicron S-carrying virus inflicts severe disease with a mortality rate of 80%.”
You do understand 80% mortality do you? Compared to 0.15% IFR we currently experience with omicron PROPER.
Now read this:
“While these mice develop lung pathology following SARS CoV-2 infection, mortality has been associated with central nervous system involvement due to viral neuroinvasion. The fact that infection with Omi-S, but not with Omicron, elicits neurologic signs, such as hunched posture and lack of responsiveness, in K18-hACE2 mice suggests that the neuroinvasion property is preserved in Omi-S, and the determinants of this property lie outside of the spike protein.”
In other words, not only is this chimera as infectious as omicron proper we have today currently circulating, but it is as pathogenic and deadly as the initial legacy Wuhan strain, yet now introduces a property that we had not seen before or did not dominate, this being lethal neurological involvement.
We can assume and extrapolate this from the humanized mice like the 8 mice the very FDA and Pfizer used to approve the new bivalent booster.
‘The recently identified, globally predominant SARS-CoV-2 Omicron variant (BA.1) is highly transmissible, even in fully vaccinated individuals, and causes attenuated disease compared with other major viral variants recognized to date. The Omicron spike (S) protein, with an unusually large number of mutations, is considered the major driver of these phenotypes.
We generated chimeric recombinant SARS-CoV-2 encoding the S gene of Omicron in the backbone of an ancestral SARS-CoV-2 isolate and compared this virus with the naturally circulating Omicron variant. The Omicron S-bearing virus robustly escapes vaccine-induced humoral immunity, mainly due to mutations in the receptor binding motif (RBM), yet unlike naturally occurring Omicron, efficiently replicates in cell lines and primary-like distal lung cells. In K18-hACE2 mice, while Omicron causes mild, non-fatal infection, the Omicron S-carrying virus inflicts severe disease with a mortality rate of 80%. This indicates that while the vaccine escape of Omicron is defined by mutations in S, major determinants of viral pathogenicity reside outside of S.’