MENACHARY & BARIC et al.: Reminder of this one study in 2015 (NATURE), key watershed moment kept quiet, "A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence"

by Paul Alexander

Publication should have given us pause for these criminals IMO told us they just created COVID of pandemic potential, with no therapeutic & could replicate efficiently in primary human airway cells


Nature Medicine volume 21, pages1508–1513 (2015)Cite this article

They told us they just conducted gain-of-function and created a pandemic chimeric coronavirus, in this one paper.

They reported (key statement):

‘…Using the SARS-CoV reverse genetics system2, we generated (means we created) and characterized a chimeric virus expressing the spike of bat coronavirus SHC014 in a mouse-adapted SARS-CoV backbone.

The results indicate that group 2b viruses encoding the SHC014 spike in a wild-type backbone can efficiently use multiple orthologs of the SARS receptor human angiotensin converting enzyme II (ACE2) (to gain entry to the host cell and in other words, infect), replicate efficiently in primary human airway cells and achieve in vitro titers equivalent to epidemic strains of SARS-CoV.

Additionally, in vivo experiments demonstrate replication of the chimeric virus in mouse lung with notable pathogenesis (that means severe ill and death).

Evaluation of available SARS-based immune-therapeutic and prophylactic modalities revealed poor efficacy; both monoclonal antibody and vaccine approaches failed to neutralize and protect from infection with CoVs using the novel spike protein. (means nothing worked even then to control and mitigate the death they created).

On the basis of these findings, we synthetically re-derived an infectious full-length SHC014 recombinant virus and demonstrate robust viral replication both in vitro and in vivo. (means we showed in the lab and outside the lab, test tube and animal that we created a deadly pandemic coronavirus with nothing capable of controlling it).

Our work suggests a potential risk of SARS-CoV re-emergence from viruses currently circulating in bat populations.’