Menachery & Baric et al.: "SARS-like WIV1-CoV poised for human emergence" (2015 to 2016 study); I want you to pay close attention to the first embedded box & the contained text; Gain-of-Function, GoF

"failure of SARS DIV vaccine to induce protection highlights the need for continued development of additional therapeutics.”; they knew the vaccine was not & could not work, they created a monster

WIV1= Wuhan Institute of Virology

This COVID injection is a bioweapon. This to me is the key statement in this 2015-2016 paper where they are telling us the nightmare they are creating and the risk it poses to humanity. These demons knew that they were playing GOD and playing with fire here yet continued juicing and ginning it up to make it more infectious and deadly, deliberately. Bottom line is that with these viruses, what they were doing with Gain-of-Function (GoF) was far too dangerous and they knew it:

“Focusing on SARS-like virus sequences isolated from Chinese horseshoe bats, the results indicate a significant threat posed by WIV1-CoV. Both full-length and chimeric WIV1-CoV readily replicated efficiently in human airway cultures and in vivo, suggesting capability of direct transmission to humans. In addition, while monoclonal antibody treatments prove effective, the SARS-based vaccine approach failed to confer protection.”

We see here they are juicing, amping up the spike protein to infect human respiratory epithelial cells. They are admitting that the vaccine cannot deal with it. In short, this bioweapon project went sideways (failed) and whether a deliberate or accidental release, the US government led this project with Wuhan/China, and they created this. Whatever they created, they could not contain it with vaccine or otherwise and are telling us here in this 2015 to 2016 research paper.

They are saying that there is an ongoing threat poised by the Wuhan Institute of Virology related viruses. This is in 2015 and 2016 as you see here.

A picture has emerged that the COVID virus and the project in the Wuhan Institute was really a US government led project. Yes, involved China and Wuhan lab, but the US led this. Why?

“Both full-length and chimeric WIV1-CoV readily replicated efficiently in human airway cultures and in vivo, suggesting capability of direct transmission to humans. In addition, while monoclonal antibody treatments prove effective, the SARS-based vaccine approach failed to confer protection. Together, the study indicates an ongoing threat posed by WIV1-related viruses and the need for continued study and surveillance.”

SOURCE:

SARS-like WIV1-CoV poised for human emergence

Outbreaks from zoonotic sources represent a threat to both human disease as well as the global economy. Despite a wealth of metagenomics studies, methods to leverage these datasets to identify future threats are underdeveloped. In this study, we describe an approach that combines existing metagenomics data with reverse genetics to engineer reagents to evaluate emergence and pathogenic potential of circulating zoonotic viruses. Focusing on the severe acute respiratory syndrome (SARS)-like viruses, the results indicate that the WIV1-coronavirus (CoV) cluster has the ability to directly infect and may undergo limited transmission in human populations. However, in vivo attenuation suggests additional adaptation is required for epidemic disease. Importantly, available SARS monoclonal antibodies offered success in limiting viral infection absent from available vaccine approaches. Together, the data highlight the utility of a platform to identify and prioritize pre-pandemic strains harbored in animal reservoirs and document the threat posed by WIV1-CoV for emergence in human populations.

“Focusing on SARS-like CoVs, the approach indicates that viruses using the WIV1-CoV spike protein are capable of infecting HAE cultures directly without further spike adaptation. Whereas in vivo data indicate attenuation relative to SARS-CoV, the augmented replication in the presence of human ACE2 in vivo suggests that the virus has significant pathogenic potential not captured by current small animal models. Importantly, therapeutic treatment with monoclonal antibodies suggests a Zmapp-based approach would be effective against a WIV1-CoV spike-mediated outbreak. However, failure of SARS DIV vaccine to induce protection highlights the need for continued development of additional therapeutics.”