Menachery et al.: "A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence"; I won't stop re-posting this one 2015 Gain-of-Function research study on bat coronaviruses

by Paul Alexander

This is key 2015 seminal study where Baric et al. told us they were doing Gain-of-Function (GoF), they had just created a monster coronavirus & it was lethal and non-responsive to drugs or vaccine

Like how America is invading itself, like how the US government under Biden is INVADING America via the Southern Border, we were also attacked from within with this COVID virus and fraud failed deadly gene injection vaccine; ‘the call is coming from inside the house’; in some sense, sick malevolent inept reckless and malfeasant people, for their own purposes attacked us from within, using US taxpayer money also to fund this and use this; we need to know the ‘WHY’? How much involvement does the US government have and was it benevolent by the US government yet taken over by dark forces for their own intent and agenda?

See who funded this study below.

IMO, it was all a lie, yet it starts here with this study to really document what these agents of death were doing and with our tax money, so about here (of course the years leading up to this publication).

This is the key watershed moment where we knew these criminals like Francis Collins and Fauci et al. were creating monster viruses that could wipe us out.

Bill Rice Jr. reminded us about the World Military Games in China in October 2019 (and how many athletes got ill with ILI) and about the satellite photos of overflowing carparks in China’s hospitals in September and October 2019. What about before? We have reports now of before. This was never ‘novel’, our immune systems saw this virus or pathogen before January 2020. This is why one spouse got hot COVID (Wuhan strain) on the Diamond Princess and was locked into their cabin 4 feet way from the other (for days and weeks), who did not get infected while the former infected partner died. The surviving spose had immunity. Some form of it.

How, when this was supposed to be the first known cruise ship outbreak? Why did the virus not burn through the entire closed ship that was quarantined off the shores, and why were there so few deaths? It was never novel. It was never lethal as they told us. It was all a lie and all we needed to know about this virus, we knew based on that Diamond Princess (DP), which was our petri dish. They just covered it up and pretended DP was not the watershed moment, the canary in the coal mine with actually ‘good’ news.

This ILI, this pathogen killed ‘low-hanging’ fruit as it should, elderly people on that ship with underlying conditions, as it did globally. 2/3 of Americans who died from COVID were elderly with at least 6 underlying medical conditions. Median age of death in February 2020 was 82 and it remains so today November 2022. With 2-3 underlying medical conditions that kills absent of COVID.

It worked just like how a respiratory virus should have worked on immuno-senescence (weakened) immune systems. It was not ‘novel’ and we should have never ever shut down society. This was done to topple Trump and IMO, kill people. My book tells you this. It is more than stolen election night votes.

We need no house or senate investigation on GoF as they told us they were doing GoF in this study and were using bat coronaviruses to do it and they had created monster viruses and I argue, it was this research (near to it) that the chimera with spillover capacity emerged. We just need to focus on this study and what flowed from it and start simply jailing these beasts. Those on the US side too for this was illegal and the evidentiary trail seems to suggest that we were taking US taxpayer money and funding illegal research on foreign soil. Yet it was our US research. We have to be open to this, such that we may have indeed created this ourselves. Who? Fauci? Not only him. Not only Francis Collins. No, several, and big high-up people. It may have been done in the Wuhan lab (with Chapel Hill North Carolina etc.) but US’s hands are all over this.

See my words bolded below as to what they meant. I insert my words in bold.

 

SOURCE:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4797993/?utm_source=substack&utm_medium=email

“The emergence of severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome (MERS)-CoV underscores the threat of cross-species transmission events leading to outbreaks in humans. Here we examine the disease potential of a SARS-like virus, SHC014-CoV, which is currently circulating in Chinese horseshoe bat populations1. Using the SARS-CoV reverse genetics system2, we generated and characterized a chimeric virus expressing the spike of bat coronavirus SHC014 in a mouse-adapted SARS-CoV backbone.”

They wrote above that they were indeed doing GoF research and they had created a chimera using virus or parts of virus and stitching it together e.g. the spike from the bat and backbone of the mouse.

“The results indicate that group 2b viruses encoding the SHC014 spike in a wild-type backbone can efficiently use multiple orthologs of the SARS receptor human angiotensin converting enzyme II (ACE2), replicate efficiently in primary human airway cells and achieve in vitro titers equivalent to epidemic strains of SARS-CoV.”

They said above that the chimeric virus they created could, via it’s spike, interact with and infect cells via the ACE II receptor on host cell membranes e.g. epithelium, and could reproduce very efficiently in human airway cells (respiratory system) and could reach pandemic proportions and strains based at that time on test tube, lab/dish experiments.

“Additionally, in vivo experiments demonstrate replication of the chimeric virus in mouse lung with notable pathogenesis.”

Above, they were able to show lethal capacity via experiments in the mouse lungs.

“Evaluation of available SARS-based immune-therapeutic and prophylactic modalities revealed poor efficacy; both monoclonal antibody and vaccine approaches failed to neutralize and protect from infection with CoVs using the novel spike protein.”

Above they are telling us that after they produced this chimeric virus, treatment and preventive drugs, as well as monoclonal antibodies (synthetic), and vaccines failed to neutralize (stop it from infecting the host, replication, or transmission).

“On the basis of these findings, we synthetically re-derived an infectious full-length SHC014 recombinant virus and demonstrate robust viral replication both in vitro and in vivo. Our work suggests a potential risk of SARS-CoV re-emergence from viruses currently circulating in bat populations.”

Above they are basically admitting that this is and was very dangerous and has tremendous pandemic potential, and they said this back in 2015. I believe the pathogen got loose just then (I believe a decision was made to hurt the POTUS electorally in 2020); this virus did not emerge in February 2020. Pharma pimped off of this to make billions, enrich themselves, dark malevolent forces used this to topple Trump. Many other players used this virus. This was created, all of it, the pandemic, the response, all of it, down to the fraud flawed 95% false-positive RT-PCR test.

 

I remind you about my book:

Order via this LINK

Research in this manuscript was supported by grants from the National Institute of Allergy & Infectious Disease and the National Institute of Aging of the US National Institutes of Health (NIH) under awards U19AI109761 (R.S.B.), U19AI107810 (R.S.B.), AI085524 (W.A.M.), F32AI102561 (V.D.M.) and K99AG049092 (V.D.M.), and by the National Natural Science Foundation of China awards 81290341 (Z.-L.S.) and 31470260 (X.-Y.G.), and by USAID-EPT-PREDICT funding from EcoHealth Alliance (Z.-L.S.). Human airway epithelial cultures were supported by the National Institute of Diabetes and Digestive and Kidney Disease of the NIH under award NIH DK065988 (S.H.R.). We also thank M.T. Ferris (Dept. of Genetics, University of North Carolina) for the reviewing of statistical approaches and C.T. Tseng (Dept. of Microbiology and Immunology, University of Texas Medical Branch) for providing Calu-3 cells. Experiments with the full-length and chimeric SHC014 recombinant viruses were initiated and performed before the GOF research funding pause and have since been reviewed and approved for continued study by the NIH. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.