miRNA (micro-RNA) and cancer? Yes, appears it has a role in immunological recognition and cancer development; "High-Throughput Analysis Reveals miRNA Upregulating α-2,6-Sialic Acid"; cancer
by Paul Alexander
Key: upregulatory miRNAs enhance overexpression of ST6GAL1 and α-2,6-sialylation, providing another potential pathway to explain the dysregulation observed in cancer and other disease states.
SOURCE:
https://pubs.acs.org/doi/10.1021/acscentsci.2c00748
‘However, the team soon replicated their findings in four cancer cell lines taken from the lungs, ovaries, pancreas, and colon. Furthermore, mutating potential miRNA binding sites caused the upregulation to disappear, suggesting that the miRNAs directly control the gene’s expression.’
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