Mishra & Banerjea: "SARS-CoV-2 Spike Targets USP33-IRF9 Axis via Exosomal miR-148a to Activate Human Microglia"; that SARS-CoV-2 gene product, Spike, is able to modify the host exosomal cargo, which
by Paul Alexander
gets transported to distant uninfected tissues and organs and can initiate a catastrophic immune cascade within within Central Nervous System (CNS)." SARS-CoV-2 mediated neurological CNS damage
In simple, cells exposed to COVID virus go on to release exosomes that carry spike protein and micro RNAs that become part of a devastating neurological sequelae. Note that as viral infection unfolds, the host cells go on to release exosomes and other extra-cellular vesicles that transport viral and host components which can modulate the immune response. The spike and microRNAs are part of this transport and are having catastrophic consequences. The key is the modulation of the immune response. Moreover, this exosomal transport pathway occurs across the body, and not just in the nervous system and we are cueing you towards not just due to natural exposure infection but due to the consequence of COVID gene injection vaccine. This is the core argument in this substack I wish you to focus on and which is that end-stage serious illness COVID symptoms are mimicked via the COVID gene injection. And remember we are also writing on the role of these extra-cellular vesicles and exosomes as they get into the vagus nerve which then creates a host of serious complications system wide given the multitude of connections the vagus nerve has to many tissues and organs etc. (especially the brain) across the body.
We are learning daily how this COVID gene injection is deadly and stand by us as we move to inform you and those willing to read and listen.
doi: 10.3389/fimmu.2021.656700.eCollection 2021.
‘SARS-CoV-2 Spike transfected cells release a significant amount of exosomes loaded with microRNAs such as miR-148a and miR-590. microRNAs gets internalized by human microglia and suppress target gene expression of USP33 (Ubiquitin Specific peptidase 33) and downstream IRF9 levels. Cellular levels of USP33 regulate the turnover time of IRF9 via deubiquitylation….
Our results also demonstrate that absorption of modified exosomes effectively regulate the major pro-inflammatory gene expression profile of TNFα, NF-κB and IFN-β. These results uncover a bystander pathway of SARS-CoV-2 mediated CNS damage through hyperactivation of human microglia. Our results also attempt to explain the extra-pulmonary dysfunctions observed in COVID-19 cases when active replication of virus is not supported. Since Spike gene and mRNAs have been extensively picked up for vaccine development; the knowledge of host immune response against spike gene and protein holds a great significance.’