Natural Killer cells (NK cells) of the innate immune system & it's Vital involvement in asymptomatic COVID infection; data show high frequency of NK cells & early IgA, IgM linked to asymptomatic COVID

by Paul Alexander

innate NK cells & the short-lived antibody response of asymptomatic individuals & patients with mild disease suggest only severe COVID-19 may result in protective memory established by the adaptive

There is a real concern about pregnant women being vaccinated due to the transfer of vaccinal antibodies to the child in utero etc. The maternal vaccinal antibodies can subvert the training of the innate antibodies in young infants, children.

Over to this piece:

Properly trained innate immunity, trained innate antibodies and NK cells can clear, abrogate infection very very early on when the person is exposed and becomes infected. The innate immunity is that potent. The innate immunity can confer sterilizing immunity to COVID virus especially in young children, young persons.

This study was very prescient and opened our eyes to the role of the innate’s NK cells in clearing out COVID pathogen and in a way indicative that with a functional innate immune system (innate antibodies and NK cells and some other components), that one would be largely asymptomatic and adaptive-acquired natural ‘memory’ immunity may not even have a major role. The adaptive-acquired may largely be mopping up after the innate has cleared the bulk of the virus. It reminded us the key and importance of ‘training’ of the innate antibodies and immune system early in childhood, the education and instructions that must take place in the young child’s innate antibodies, and the critical nature of the COVID injection vaccinal antibodies that are non-neutralizing, and that would undermine the innate’s training, would bind to the spike antigen but not sterilize it, and would subvert and block the innate antibody training. The innate antibodies must bind to live viruses to be trained. To the extent that a negative PCR test and the absence of symptoms (asymptomatic) or mild in people that got firmly exposed can only really be explained by cell-based innate immunity (i.e., ‘trained’ innate antibodies and NK cells).

So much so that exposed persons would even present with low or no antibodies given the initial first line of defense potent role of the innate immune system’s NK cells is clearing virus. These people will largely be asymptomatic and if any, with mild symptoms, with very short-lived antibodies that are very weak and cannot neutralize the virus. In other words the innate did the job.

“SARS-CoV-2 is a novel coronavirus, not encountered before by humans. The wide spectrum of clinical expression of SARS-CoV-2 illness suggests that individual immune responses to SARS-CoV-2 play a crucial role in determining the clinical course after first infection. Immunological studies have focused on patients with moderate to severe disease, demonstrating excessive inflammation in tissues and organ damage. In order to understand the basis of the protective immune response in COVID-19, we performed a longitudinal follow-up, flow-cytometric and serological analysis of innate and adaptive immunity in 64 adults with a spectrum of clinical presentations: 28 healthy SARS-CoV-2-negative contacts of COVID-19 cases; 20 asymptomatic SARS-CoV-2-infected cases; eight patients with Mild COVID-19 disease and eight cases of Severe COVID-19 disease.”

Data show that elevated frequency of NK cells and “early and transient increase of specific IgA, IgM and, to a lower extent, IgG are associated with asymptomatic SARS-CoV-2 infection. By contrast, monocyte expansion and high and persistent levels of IgA and IgG, produced relatively late in the course of the infection, characterize severe disease. Modest increase of monocytes and different kinetics of antibodies are detected in mild COVID-19. The importance of innate NK cells and the short-lived antibody response of asymptomatic individuals and patients with mild disease suggest that only severe COVID-19 may result in protective memory established by the adaptive immune response.”


Different Innate and Adaptive Immune Responses to SARS-CoV-2 Infection of Asymptomatic, Mild, and Severe Cases