Ndeupen et al; "The mRNA-LNP platform's lipid nanoparticle component used in preclinical vaccine studies is highly inflammatory"; mice model but instructive showing lipid nanoparticles 'inflammatory'

Key statement: 'The same dose of LNP delivered intranasally led to similar inflammatory responses in the lung and resulted in a high mortality rate, with mechanism unresolved.'

“Intradermal and intramuscular injection of these LNPs led to rapid and robust inflammatory responses, characterized by massive neutrophil infiltration, activation of diverse inflammatory pathways, and production of various inflammatory cytokines and chemokines. The same dose of LNP delivered intranasally led to similar inflammatory responses in the lung and resulted in a high mortality rate, with mechanism unresolved. Thus, the mRNA-LNP platforms' potency in supporting the induction of adaptive immune responses and the observed side effects may stem from the LNPs' highly inflammatory nature.”

SOURCE in CELL:

The mRNA-LNP platform's lipid nanoparticle component used in preclinical vaccine studies is highly inflammatory