OMINOUS 2016 paper (in PNAS) by Menachery & Baric (Chapel Hill North Carolina) titled "SARS-like WIV1-CoV poised for human emergence"; the results indicate that the WIV1-coronavirus (CoV) cluster has
by Paul Alexander
the ability to directly infect and may undergo limited transmission in human populations. available SARS monoclonal antibodies offered success in limiting viral infection
This 2016 PNAS paper by Menachery and Baric adds to the NATURE publication in 2015. They were actually documenting for us the madness they were doing with gain-of-function (GoF) chimeric research and that they actually were and did create pandemic coronaviruses.
The emergence of severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome (MERS)-CoV highlights the continued risk of cross-species transmission leading to epidemic disease. This manuscript describes efforts to extend surveillance beyond sequence analysis, constructing chimeric and full-length zoonotic coronaviruses to evaluate emergence potential. Focusing on SARS-like virus sequences isolated from Chinese horseshoe bats, the results indicate a significant threat posed by WIV1-CoV. Both full-length and chimeric WIV1-CoV readily replicated efficiently in human airway cultures and in vivo, suggesting capability of direct transmission to humans. In addition, while monoclonal antibody treatments prove effective, the SARS-based vaccine approach failed to confer protection. Together, the study indicates an ongoing threat posed by WIV1-related viruses and the need for continued study and surveillance.