Persistent circulating SARS-CoV-2 spike as much as 12-months after infection in COVID patients, is associated with post-acute COVID-19 sequelae; supports work by Patterson et al. and McCullough

by Paul Alexander

I owe thanks to Dr. Ramin Oskoui who raised a debate with me in this & shared this key paper; we agree this raises the reality that spike persists post COVID injection too; a HUGE problem; LONG-COVID?

Yes, we agree that this helps explain, at least in part, long-COVID.


Persistent circulating SARS-CoV-2 spike is associated with post-acute COVID-19 sequelae

“We analyzed plasma samples collected from a cohort of PASC and COVID-19 patients (n = 63) to quantify circulating viral antigens and inflammatory markers. Strikingly, we detect SARS-CoV-2 spike antigen in a majority of PASC patients up to 12 months post-diagnosis, suggesting the presence of an active persistent SARS-CoV-2 viral reservoir. Furthermore, temporal antigen profiles for many patients show the presence of spike at multiple time points over several months, highlighting the potential utility of the SARS-CoV-2 full spike protein as a biomarker for PASC.”