Pfizer documents: A Tissue Distribution Study of a [3H]-Labelled Lipid Nanoparticle-mRNA (LNP) Formulation Following Intramuscular Administration in Wistar Han Rats; dramatic increases in ovaries

by Paul Alexander

Table 1, page 23 shows Total Lipid Concentration at 48 hours; very ELEVATED LNP concentrations in adrenals, injection site, liver, ovaries, bone marrow; ovaries dramatic increases 0.25 min to 48 hours

This document (tissue distribution study) was hidden among Pfizer documents and was ordered to be released by the courts. This was one of the documents Pfizer wanted kept hidden for 75 years.

In terms of lipid nano-particle tissue distribution from the Pfizer injection: A key finding is that lipid concentration rises from 0.104 at 0.25 minutes post injection to 12.261 at 48 hours in ovaries. This is a red flag for damage to fertility and these findings (concentration levels and increases in tissue across time) mirrors the Japanese biodistribution Pfizer study (FOIA) data.


‘Wistar Han rats (21 male and 21 female) each received a single intramuscular dose of [ 3 H]-08-A01-C01 at a target mRNA total dose of 50 µg/animal (1.29 mg/animal total lipid dose). The content and concentration of total radioactivity in blood, plasma and tissues were determined at pre-defined time points following administration. Whole blood and tissue samples were collected at 0.25 1, 2, 4, 8, 24 and 48 hours post-dose (three animals/sex/timepoint) and plasma was subsequently separated from blood by centrifugation. The concentration of total radioactivity was measured by liquid scintillation counting (LSC).’