"Pre-exposure to mRNA-LNP inhibits adaptive immune responses & alters innate immune fitness in an inheritable fashion" (Qin et al.); mRNA-LNP vaccine platform induces long-term unexpected immunologic
by Paul Alexander
changes affecting both adaptive immune responses and heterologous protection against infections; mice pre-exposed to mRNA-LNPs can pass down the acquired immune traits to their offspring.
This study adds to the body of evidence that the mRNA COVID injection re-arranges and subverts the natural innate and adaptive immune systems, and raises the potential of the subversion to be passed on to off-spring (animal model thus far yet we may extrapolate).
The mRNA-LNP-based SARS-CoV-2 vaccine is highly inflammatory, and its synthetic ionizable lipid component responsible for the induction of inflammation has a long in vivo half-life. Since chronic inflammation can lead to immune exhaustion and non-responsiveness, we sought to determine the effects of pre-exposure to the mRNA-LNP on adaptive immune responses and innate immune fitness. We found that pre-exposure to mRNA-LNPs or LNP alone led to long-term inhibition of the adaptive immune responses, which could be overcome using standard adjuvants. On the other hand, we report that after pre-exposure to mRNA-LNPs, the resistance of mice to heterologous infections with influenza virus increased while Candida albicans decreased. The diminished resistance to Candida albicans correlated with a general decrease in blood neutrophil percentages. Interestingly, mice pre-exposed to the mRNA-LNP platform can pass down the acquired immune traits to their offspring…the mRNA-LNP vaccine platform induces long-term unexpected immunological changes affecting both adaptive immune responses and heterologous protection against infections.
In summary, the mRNA-LNP vaccine platform induces long-term immunological changes that can affect both adaptive immune responses and heterologous protection against infections, some of which can be inherited by the offspring.’