Röltgen et al.: "Immune imprinting, breadth of variant recognition, & germinal center response in human SARS-CoV-2 infection & vaccination"; Original antigenic sin, OAS & vaccine mRNA 60 days post jab
by Paul Alexander
"detected vaccine mRNA collected in the GCs of LNs on days 7, 16, and 37 postvaccination, with lower but still appreciable specific signal at day 60"
Key study in CELL and helped verify aspects of this COVID virus in terms of immunological response post vaccine; showed us the immunological fixation, or imprinting, or prejudice to the initial exposure e.g. if initial exposure is to legacy Wuhan strain, the antibody response will principally be to the legacy strain; and that the content of the vaccine e.g. LNP and mRNA persists prolonged in the body and we can infer spike is also manufactured cellularly (translated) long-term, no ‘off’ switch. There was prolonged detection of vaccine mRNA in LN germinal cells and spike antigen in LN germinal cells and blood following SARS-CoV-2 mRNA vaccination.
Immune imprinting, breadth of variant recognition, and germinal center response in human SARS-CoV-2 infection and vaccination