Shocking European research finds COVID spike protein accumulates in skull-meninges brain axis (mouse models & human post-mortem tissues); accumulation of spike protein in skull marrow, brain meninges

by Paul Alexander

& brain parenchyma; injection of spike protein alone caused cell death in brain, presence of spike protein in the skull of deceased long after their COVID infection; can extrapolate to mRNA shot

The key aspect of this paper is that is shows that the mRNA technology based gene injection resulting spike protein (deadly spike protein) do end up and accumulate in the skull marrow, brain meninges & brain parenchyma. This paper clarifies that the spike protein (content of the mRNA technology based gene injection and resulting translated spike) punctures the blood brain barrier. The declarative cardiovascular damage and continuously clarified neurological damage (as seen here) from the COVID gene injections seems extensive.

What did the study report?:

Start here:

‘Results revealed the accumulation of the spike protein in the skull marrow, brain meninges, and brain parenchyma.

The injection of the spike protein alone caused cell death in the brain, highlighting a direct effect on brain tissue.

Observed the presence of spike protein in the skull of deceased long after their COVID-19 infection, suggesting that the spike’s persistence may contribute to long-term neurological symptoms.

The spike protein was associated with neutrophil-related pathways and dysregulation of the proteins involved in the PI3K-AKT as well as complement and coagulation pathway.

Findings suggest that SARS-CoV-2 spike protein trafficking from CNS borders into the brain parenchyma and identified differentially regulated pathways may present insights into mechanisms underlying immediate and long-term consequences of COVID’ & these results can be extrapolated to the effects from the mRNA-DNA injection. IMO, the impact from the gen injection may be far more devastating given the molecular adaptations made to the synthetic MOD-mRNA.


Dr. Christof Plothe also added his description of the study:

‘Out of all COVID-19 viral proteins, only the spike protein was detected in brain parenchyma. 

suggesting that the spike protein could have a long lifetime in the body. This notion is supported by the observation that spike protein can be detected on patient immune cells more than a year after the infection - a recent preprint suggests spike protein’s persistence in plasma samples up to 12 months post-diagnosis”

“injection of spike protein induced a broad spectrum of proteome changesin the skull marrow, meninges, and brain, including proteins related to coronavirus disease, complement and coagulation cascades, neutrophil degranulation, NETs formation, and PI3K-AKT signaling pathway, demonstrating the immunogenicity of SARS-CoV-2 spike protein in the absence of other viral components.”

Brain inflammation

“Our molecular analysis suggests activation of immune response in the skull-meninges-brain axis, potentially via recruiting and increasing the activity of neutrophils similar to what has been reported in the respiratory tract”

in the skull marrow…viral proteins act as an inflammatory stimulus that leads to the development of a significant immune response in the brain”

In the meninges, a significant consequence of the inflammatory state is an upregulation of proteins involved in neutrophil degranulation”

“Proteins related to the neurodegeneration pathway and damage to the blood-brain barrier were the most prominent dysregulated molecules in the brain.”

“viral spike protein leads to the activation of RHOA, which triggers the disruption of blood–brain barrier

Blood clots, mini-strokes, brain bleeds

“The dysregulation of the complement and coagulation pathways was detected in both the skull marrow and the brain. This might explain the observed propensity of COVID-19 patients to develop mini-infarcts in the brain parenchyma and our observation of an increased level of micro-bleedings in COVID-19 patients, potentially contributing to the observed brain damage in the COVID-19 patients in acute or chronic stages”

Spike protein and Neurological diseases

“We identified several candidate proteins with no previous association with COVID-19, especially those earlier associated with neurological diseases…notably, their role has been associated with disorders such as Parkinson’s disease, Alzheimer’s disease, and dementia

“To further pinpoint the consequences of spike protein-specific effects in the brain tissue beyond the acute inflammatory response…We identified several dysregulated proteins associated with neurodegeneration

significantly impairs mitochondrial function…a source of oxidative stress reported in…long-term symptoms such as chronic fatigue

How Spike protein gets into the brain

“Our data may also suggest a mechanism for the virus’s entry into the central nervous system. In both mouse and COVID-19 human tissues, we find spike protein in the SMCs (skull-meninges connection), which the virus or virus components could use to travel from the skull marrow to the meninges and the brain parenchyma

“virus might take other routes to reach the brain in a not mutually exclusive way. For example, the virus could traverse the cerebrovasculature to reach the brain parenchyma or be carried there by immune cells (via neutrophils or phagocytic cells)”

“Brain invasion of virus-shed spike protein found in some COVID-19 cases has been linked to a compromised blood-brain barrier and trafficking along the olfactory nerve or vagus nerve. Here, we suggest an alternative scenario wherein SARS-CoV-2 spike protein reaches first the skull marrow and then the meninges before entering the brain.”

Spike-induced alterations in the skull-meninges-brain axis present diagnostic and therapeutic opportunities as both skull and meninges are easier to access than brain parenchyma”’