Singapore: What is happening? same as in Germany & other nations that are highly vaccinated, we see surges in infection, cases, hospitalization & death & due to the non-neutralizing antibodies (Abs)
by Paul Alexander
See selected global nations yet see Singapore, its cases, vaccine rate, & excess mortality; again, it is interplay between the virus and the population immunity, specifically the non-neutralizing Abs
If the aim is a slow kill, harm, maintaining of this pandemic, if the aim is to drive infectious variant after infectious variant and including more virulent ones, if the aim is to harm the population, if the aim is to keep this pandemic going for 100 more years, then we keep vaccinating with these same vaccines, same way. Change nothing!
The high-affinity, vaccine induced antibodies are non-neutralizing and pressuring the infectiousness and virulence of the virus (binding epitopes, receptor binding domain and N-terminal domain). We are driving a dangerous situation if these failed COVID injections are not stopped and the new bivalent booster will create further disaster. These people have no idea what they are doing and I can only say now it is wickedness, not just ineptness. Wickedness.
see Fantini et al:
see Liu et al:
A key phrase:
‘some of antibodies against the N-terminal domain (NTD) induced the open conformation of RBD and thus enhanced the binding capacity of the spike protein to ACE2 and infectivity of SARS-CoV-2.’
As you see, a highly vaccinated nation, waves not getting back to baseline (so no herd immunity) and thus you cannot tame or end a pandemic if you do not cut the chain of transmission and get to herd immunity.