Solanki et al.: "Evasive spike variants elucidate the preservation of T cell immune response to the SARS-CoV-2 omicron variant"; we say 'so what'? so what if there is cross-reactivity? Can it confer
by Paul Alexander
sterilizing immunity to tame the pandemic and destroy infected cells? Is there cytotoxic, cytolytic capacity? If not, so what? So what if reactive to epitopes across a multitude of variants?
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Geert Vanden Bossche has always been correct here, such that if there is ‘no evidence whatsoever that there is widespread induction of cytolytic memory T cells capable of killing SC-2-infected host cells’, then so what? Point is if there is no yet shown cytotoxic or cytolytic capacity of T-cells as to virus infected cells, then it cannot constrain viral transmission and if you cannot cut the chain of transmission, then you cannot tame the pandemic.