Spike protein may initiate (via COVID gene therapy injection or infection) a catastrophic immune cascade within the Central Nervous System (CNS); Mishra et al.: "SARS-CoV-2 Spike Targets USP33-IRF9...

by Paul Alexander

USP33-IRF9 Axis via Exosomal miR-148a to Activate Human Microglia"; Spike, is able to modify the host exosomal cargo, which gets transported to distant uninfected tissues and organs

We again extrapolate the destruction caused by the spike protein whether via natural infection or via COVID gene injection vaccine.

SOURCE:

https://www.frontiersin.org/articles/10.3389/fimmu.2021.656700/full

‘SARS-CoV-2, the novel coronavirus infection has consistently shown an association with neurological anomalies in patients, in addition to its usual respiratory distress syndrome. Multi-organ dysfunctions including neurological sequelae during COVID-19 persist even after declining viral load. We propose that SARS-CoV-2 gene product, Spike, is able to modify the host exosomal cargo, which gets transported to distant uninfected tissues and organs and can initiate a catastrophic immune cascade within Central Nervous System (CNS). SARS-CoV-2 Spike transfected cells release a significant amount of exosomes loaded with microRNAs such as miR-148a and miR-590. microRNAs gets internalized by human microglia and suppress target gene expression of USP33 (Ubiquitin Specific peptidase 33) and downstream IRF9 levels. Cellular levels of USP33 regulate the turnover time of IRF9 via deubiquitylation. Our results also demonstrate that absorption of modified exosomes effectively regulate the major pro-inflammatory gene expression profile of TNFα, NF-κB and IFN-β. These results uncover a bystander pathway of SARS-CoV-2 mediated CNS damage through hyperactivation of human microglia. Our results also attempt to explain the extra-pulmonary dysfunctions observed in COVID-19 cases when active replication of virus is not supported. Since Spike gene and mRNAs have been extensively picked up for vaccine development; the knowledge of host immune response against spike gene and protein holds a great significance. Our study therefore provides novel and relevant insights regarding the impact of Spike gene on shuttling of host microRNAs via exosomes to trigger the neuroinflammation.’

 

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