The ineffective and harmful COVID gene injection (vaccine) and why injecting children can be very dangerous to their developing INNATE immune systems: why our ‘elderly’ elderly, remain at risk

by Paul Alexander

COVID is not over for our 'elderly' elderly & continuing this sub-optimal ineffective vaccine in the midst of heavy infectious pressure can & will drive more infectious (and lethal) variants to emerge

This is my opinion and how I see things at present.

Critically before I unfold this offering, a key point must be tabled. This is that we have underestimated the evolutionary biology and the dynamics at play between the COVID virus (coronavirus, respiratory virus) and the resulting immune response from the population, either via natural infection or vaccine. Those making decisions have disregarded the evolutionary capacity of the virus to adapt and evolve due to the population immune pressure (mounting). Especially if the immune response is sub-optimal and immature with immune fixation and priming (prejudice) that has induced vaccinal antibodies that do not neutralize the antigen (in this case Wuhan vaccine spike facing omicron BA.5 spike/clade).

This interplay and dance between virus and host immune system should have been the cardinal issue on day one for today, we are faced with infectious variant after infectious variant due to the non-sterilizing, non-neutralizing vaccine (vaccinal antibodies) that do not stop infection or transmission, placing the spike and binding domains under massive Darwinian selection pressure to select for the more ‘fitter’ variants. The danger is that we can drive the emergence of a more virulent lethal sub-variant clade.

They have disregarded and do not understand the critical role of the ‘balance’, the natural balance and dynamic equilibrium that exists, and must exist between the virus and the immune system of the host and the drive is always towards getting there.

The COVID pandemic would have been over more than 2 years ago yet it is continuing with expansion due to the use of the existing non-neutralizing COVID injections that do not stop infection, replication, or transmission, and in fact, drives emergence of infectious sub-variants (and a potentially virulent/lethal one). The Omicron virus (sub-variants) is largely resistant to the potentially neutralizing and non-neutralizing antigen-specific, vaccine induced antibodies (Abs).

 

Importantly, I am arguing that our ‘ELDERLY elderly’ (distinct from those who are of age e.g. 80 and above, but are generally healthy), those above 80 with medical conditions, are at an unique period of vulnerability and we must guard them now as in February 2020. Why? They have been locked down for 2.5 years with an already immune-senescence immune system declined due to aging, that has been further dampened down to basically nothing. This is one of the ramifications of the lockdown lunacy. Same in our children in terms of lockdowns and school closures weakening their immune systems. But for the ‘elderly’ elderly, with no immune capacity or very little, and with a COVID gene injection that was promised to eliminate the virus and stop infection and transmission, they are basically defenseless as we ‘open up’. Mild omicron can present devastating challenges to them, with pneumonia setting in rapidly etc.  

Nasal-oral washes, prophylaxis and preventive early treatment, vitamin D, the whole kitchen sink, sensible precautions, do not think OMI is mild for them. Their immune system is weaker than ever now as it was constrained. Those with conditions.

COVID in my opinion is not over for the ‘elderly’ elderly for there is no vaccine that protects the upper airways, does not stop severe illness or death, and they have a near destroyed immune system due to lockdowns. Omicron BA.5 sub-variant clade today, as mild as it is (common-cold symptoms etc. and largely asymptomatic sequelae), is as if our ‘elderly’ elderly are now facing the more lethal Wuhan strain in February in 2020 that killed the low-hanging fruit.

I want you to think about this and take precautions with your ‘elderly’ elderly, it is not over for them and the lockdowns have harmed them. The failed gene injection vaccine has harmed them for not only does it not work (rapid waning immunity and negative efficacy and promotes re-infection in the vaccinee), it is also catastrophically harmful for them. I decided to state this up top so that you get a sense that this is still not over for a portion of our population yet it can become much more grave for the rest of the population due to the sub-optimal vaccinal immune pressure on the target antigen. Those involved in this vaccine and pandemic fail and failed to understand the interplay between the virus itself and the population immune response. Each places pressure on the other and there is evolution of the virus in response. How?

First, this COVID gene injection must be stopped! It has failed, ineffective, and harmful. There is no other way for me to say it other than it must be stopped. The vaccine is driving massive infectious pressure and keeping virus circulating and vaccinated persons spreading the virus. It is that simple and ominous. Very early on I wrote a review in Brownstone showing that there was no difference between the vaccinated and the unvaccinated and that the vaccine was failing. Brownstone, Dr. Paul Alexander

Omicron is the latest variant (and it’s subvariants/clades) since the initial Wuhan legacy strain (some estimates are that the initial emergence could be sometime late 2018 and early to mid-2019) and has evolved into a mild ‘common cold’ sub-variant (BA.4 & BA.5) that one can argue could become (or already is) endemic and circulate seasonally as a common cold like coronavirus e.g. alike OC43 and 229E. However, the high specificity and largely resistant, vaccinal Abs are placing the spike glyco-protein (binding sites such as the receptor binding domain and the N-terminal domain) of the SARS-CoV-2 virus under sub-optimal immune pressure.

This pressure on the spike is causing the selection (via Darwinian natural selection) of more infectious (evolutionary fittest) variants that could overcome the pressure with viral immune escape (antibody-dependent enhancement of infection (ADEI) as well as antibody-dependent enhancement of disease (ADED)) and original antigenic sin (whereby there is immune fixation or immune locking or priming or prejudicing based on the initial prime or exposure).

The result is that those who are vaccinated are at enhanced risk of infection (due to infection-enhancing vaccinal antibodies) and those who are not vaccinated, have benefitted from infection-mediated training of innate cell-mediated immunity (the training, education, and instructing of the innate immunity and the critical role of the innate antibodies in this training). This training is based on massive infectious pressure. Theoretically, this pandemic can continue for many years if the use of these sub-optimal non-neutralizing gene injections is not stopped. Infectious variant after infection variant will emerge and a potentially infectious variant that is more virulent, causing severe disease, can emerge.  For additional reading, please refer to:

i)Liu et al. “An infectivity-enhancing site on the SARS-CoV-2 spike protein targeted by antibodies” and

ii)Fantini & Yahi et al. “Infection-enhancing anti-SARS-CoV-2 antibodies recognize both the original Wuhan/D614G strain and Delta variants. A potential risk for mass vaccination?

While there was some protection of the upper respiratory airways in the pre-Omicron era, with the exiting (dominant) Omicron sub-variants (BA.4 & BA.5) that are largely resistant to vaccinal neutralizing antibodies, the vaccinated persons have become more susceptible to infection and we are witnessing more virulent variants becoming dominant (Omicron subvariants BA.4 and BA.5). “Neutralization experiments revealed that the immunity induced by BA.1 and BA.2 infections is less effective against BA.4/5. Cell culture experiments showed that BA.2.12.1 and BA.4/5 replicate more efficiently in human alveolar epithelial cells than BA.2, and particularly, BA.4/5 is more fusogenic than BA.2.”  

Importantly, virulence-neutralizing antibodies (Abs) (these are the same as those enhancing/facilitating infection at the upper respiratory tract) still protect against severe disease in the vaccinated person (e.g., in the case of BA.1 and BA.2) in the lower respiratory tract. However, it is very likely that with the growing resistance of BA.4 and BA.5 clades to the virulence-neutralizing Abs, then vaccinated persons will quickly become more susceptible to virulence. This is a major concern.

Widespread asymptomatic transmission in highly vaccinated nations and the subsequent rise in infectious pressure (due to circulating virus in the midst of the pandemic) is causing infection-mediated immunity in certain subsets of the population to no longer suffice to prevent productive infection. As a result, we are seeing a rise in the global spread of a number of acute, self-limiting microbial infections (e.g., ‘seasonal’ flu, RSV but also vaccine-preventable viral and bacterial infections in countries that interrupted their childhood vax program due to Covid crisis) and also of some acute, self-limiting viral diseases (e.g., monkeypox, potentially pandemic [avian H5N1] flu).

In addition, depletion (and immune exhaustion) of cytotoxic CD8+ T-cells due to repetitive cycles of re-infection has also led to an increased recurrence/reactivation rate of chronic infections (e.g., herpetic diseases, CMV, EBV, CMV, HIV, tuberculosis etc.) and relapse or metastasis of certain cancers in vaccinees.

Dr. Geert Vanden Bossche continues to explain how the COVID mass vaccination has failed and mainly drives natural selection and the expansion in prevalence of infectious variants that are not neutralized. Viral immune escape ensues whereby the virus e.g. omicron BA.4/BA.5 clades, escapes the potentially neutralizing vaccinal antibodies. The reality is that a pandemic can provide the type of protective sterilizing immunity that no current vaccine is able to provide.

As Vanden Bossche explains, ‘the resulting herd immunity is typically broadly protective and sterilizing and therefore dramatically reduces viral transmission. No single vaccine can provide protective population immunity when used during a pandemic. Mass vaccination campaigns result in a type of population immunity that has exactly the opposite effect in that they promote viral transmission by virtue of natural selection of more infectious immune escape variants.’

As trained innate immunity is a cornerstone of herd immunity, all efforts to protect the population should focus on enabling herd immunity in ways that keep hospitalization and morbidity rates as low as possible. Vaccines will ultimately have the opposite effect whereas strengthening the population’s innate immune system (via healthy lifestyle) while avoiding overcrowding combined with early outpatient treatment of those with a weakened innate immune system (e.g., the elderly and those with underlying disease) are the holy grail for effectively and rapidly driving the virus into endemicity and minimizing the toll on human lives (Dr. Geert Vanden Bossche); note, much of my vaccinology and to an extent virology education has flown from Dr. Vanden Bossche of which I am very grateful. He has polished me and I think in a class of his own. Much of what, and how I lay this paper out is based on what he has said and written and I must give him full credit for educating us all.

Advice on if you are not COVID-19 injected:

i) Dr. Geert Vanden Bossche warns (and I concur and write it how best I can) that under no condition get the seasonal Flu shot as vaccination with Flu vaccines that are inactivated can intensely increase the risk of antibody-dependent enhancement of infection (ADEI) if you were exposed to avian flu.

ii) Dr. Geert Vanden Bossche warns (and I concur) that you must not be in receipt of a non-replicating smallpox vaccineSince surface proteins of smallpox (via use of cowpox as live attenuated immunogen) are different from those decorating the monkeypox virus, and as the non-replicating vaccine primarily induces Abs, you could expose yourself to a substantial risk of ADEI.

iii) COVID-19 unvaccinated people do not require a smallpox injection at all (and moreover, they do not need an avian Flu vaccine either – in case the industry comes up with a pandemic flu vaccine!) and regardless of whether they received the smallpox vaccine in the past.

Training of our innate immune system against Coronavirus (i.e., SARS-CoV-2) during the ongoing COVID-19 pandemic will not only provide strong innate immune protection against influenza virus and poxviruses but also against other glycosylated viruses causing acute, self-limiting infection (e.g., RSV, other common cold coronavirus).

Upon exposure to monkeypox or avian Flu, an unvaccinated person for COVID-19 and who is in good health and has experienced mild or moderate COVID-19 symptoms as a result of previous natural infection (due to the ongoing pandemic) may still get some mild illness yet the response will not be that serious. This will just induce additional antibodies which will function to fully protect you the next time around, and operates much like a live attenuated viral vaccine does. There is even a high likelihood that there will not be a ‘vaccine take’ when you are vaccinated with live attenuated smallpox as your trained natural killer (NK) cells may kick out the vaccinal virus right away.

However innate immune training against COVID virus will not protect against measles, mumps, rubella or varicella. As such,

iv) We suggest that you vaccinate your child against these childhood diseases (measles, mumps, rubella or varicella) before local outbreaks/ epidemics occur. It is never a good idea, and this could be dangerous for the child, to get the MMRV shot during a situation of elevated infectious pressure. Also, it is not recommended to vaccinate older children / adults/ elderly with these live attenuated vaccines if they have not been vaccinated against those diseases before. As such, those who didn’t receive these childhood vaccines and did not acquire natural immunity as a result of previous natural infection are at risk of contracting the disease in case of an outbreak.

Unvaccinated elderly and vulnerable people (e.g., with co-morbidities) have a risk of contracting moderate to severe disease from Flu or RSV. The likelihood for developing severe disease increases when the innate immune system is weakened, especially in case of exposure to high infectious pressure (the latter could, for example, rapidly build up in areas of high population density such as nursing homes). One should always consider removing their parent/ grand-parents from nursing homes.

v) Live attenuated smallpox vaccine will not work in COVID-19 vaccinees. This is because host cells that are infected with vaccinal virus will be readily recognized and killed by cytotoxic CD8+ T-cells that are continuously activated due to the enhanced susceptibility of vaccinees to re-infection.

vi) COVID-19 vaccination of children must stop immediately. Not only will the COVID-19 vaccines fully prevent innate antibodies from neutralizing the virus (binding to the antigen and neutralizing), but they will also irreversibly prevent the innate antibodies (in association with the virus) from educating the cell-based innate immune system (e.g., NK cells that are part of the innate immune system). Instead, the vaccinal antibodies will bind to the spike antigen and facilitate and enhance viral infectiousness and enable the virus to breach the innate immune defense, thereby causing severe COVID-19 disease.

This binding by vaccinal Abs and out-competing of the innate Abs will also prevent the child from educating it’s innate immune system in recognizing several other (glycosylated) pathogens while discriminating those from self-antigens (discriminating self from non-self, self-like, self-mimicking etc). This could lead to severe disease caused by several other (glycosylated) pathogens which the child has not been vaccinated against as well as to severe immune pathology e.g. auto-immune disease In addition, it will also no longer be possible to vaccinate children with other live attenuated childhood vaccines once they have received the COVID-19 shot for these vaccines could now cause severe disease. So, in effect, the COVID-19 vaccine could become a death sentence for a young child!

Dr. Geert Vanden Bossche advises that the only way to bypass the malevolent COVID-19 priming is to properly educate the vaccinee’s innate immune effector cells in the absence of replicating virus. It will be critical to treat them as of the early onset of symptoms. Treatment with antivirals shortly after infection could possibly train their innate immune system without boosting their infection-enhancing antibodies.

What are we saying about these COVID injections (mass vaccination) for children?

A rapid mass vaccination campaign that utilizes a sub-optimal antigen-specific non-neutralizing vaccine (such as the COVID vaccines) and with vaccination across all age groups, and into the pandemic (in the midst of an active pandemic of a highly mutable and highly infectious respiratory virus with high infectious pressure) can only generate a continued series of dominating new variants that are increasingly infectious, increasingly vaccine-resistant (due to “immune escape”), and inevitably more virulent (potentially lethal).  In short, the mass vaccination campaign that has been implemented during the COVID pandemic can potentially keep the pandemic going for many years with a potential more virulent sub-variant emerging.

Importantly, children bring statistical zero risk of severe illness or death from this COVID virus and this was the same across near 3 years. The data is stable. In the US, no healthy child, same in Sweden, Germany etc. has died from COVID due to being infected, across near 3 years. Not one! This is the data the media will not tell you. The immune system of children needs to be educated and trained for life-long optimal functionality. The vaccine implementation will damage and subvert the initiation of education and instruction of the innate immune system in children (the first line of immunological defense).  It is critical that you as parents understand this.

Parents must understand that when the COVID injection is given to young children, this (the vaccinal antibodies that are induced due to the vaccine) prevents the child’s innate antibodies from eliminating the virus confronted with now, and prevents the active training and teaching of the innate immune effector cells on how to recognize (glycosylated) viruses and distinguish them from “self” antigens (i.e., distinguish between “self” and “non-self.”).

This is a critical window of training for any immune system to learn at an early stage of life (once passive maternal immune protection is no longer available e.g. at about 4 to 6 months post birth) so as to provide for a healthy and appropriate immune response, immediate and life-long. This interference with the initiating foundational education of a child’s developing innate immune system can cause a COVID-vaccinated child to be less capable of handling glycosylated viruses (and glycosylated pathogens in general, as well as a range of pathogen). This predisposes such children to immune pathology (e.g., autoimmune disease).