Van Egeren et al.: “Risk of rapid evolutionary escape from biomedical interventions targeting SARS-CoV-2 spike protein”; this one study by Van Egeren was pivotal and scientific community ignored it

by Paul Alexander

I wanted to share this paper for it is seminal and I will highlight key phrases for you to focus on; these researchers told us the vaccine was junk early on and the approach was doomed to fail

Let me ask a simple question: Why would the epidemic waves be coming so close together across nations after successive waves? Why are the declines not getting back to baseline? Why are the omicron waves staying above baseline? We should be getting back to baseline after each curve declines. Why also are the peaks higher than the prior peak? How can a vaccine protect against severe illness but not mild illness? How can you be susceptible to infection yet protected against severe illness?

We can never ever get to control this pandemic if we do not get to herd immunity. Ever! We failed! I do not care what press idiot or moron or scientists attacks me, I said day 1. Natural immunity is superior and key. We allow the infant, kids, young and healthy to be exposed naturally and harmlessly, the healthy with robust immune systems, to live normal lives and be exposed so as to develop natural immunity. Their strong robust immune system would be able to handle the variants. This is not changed.

How can you tell me we have a vaccine that does not stop infection but protects you against serious disease?

Truth is Omicron proved us right, Geert, Malone, myself, Bridle etc. We have been saying one year now that if you use a non-sterilizing vaccine (with non-neutralizing antibodies) that does not cut transmission (neutralization/elimination of the virus), you will drive variants. The pandemic will never end if this failed vaccine is not stopped. If we prime the population massively and especially children, we will damage and subvert the natural INNATE immune system (suppressing INNATE while the natural acquired-adaptive immunity antibodies are sub-optimal and worthless, miss-matched to the present variants) and this can be catastrophic for humanity. We are preventing the population from getting to population-level herd immunity with these non-sterilizing vaccines; we will never ever get to herd immunity.

Fauci et al., CDC, NIH etc. have zero understanding of this pandemic and what is happening with the virus and the vaccine they imposed on us. You can only tamp down or calm a pandemic if you cut the chain of transmission and these vaccines do not do this, PERIOD! These vaccines have failed! CDC, NIH, Fauci, Francis Collins, Bourla of Pfizer etc. know this. They are lying to you! These vaccines are not inducing neutralizing antibodies and the virus is resistant to these neutralizing antibodies.

This technical paper is written so very well, so much of ease of flow, I need not explain much as I am aware how in-tuned and adept you are on COVID and these vaccines. Key nuggets are in this paper:


Van Egeren et al.: “Risk of rapid evolutionary escape from biomedical interventions targeting SARS-CoV-2 spike protein


1)”The spike protein receptor-binding domain (RBD) of SARS-CoV-2 is the molecular target for many vaccines and antibody-based prophylactics aimed at bringing COVID-19 under control. Such a narrow molecular focus raises the specter of viral immune evasion as a potential failure mode for these biomedical interventions.

2)The speed at which nAb resistance develops in the population increases substantially as the number of infected individuals increases, suggesting that complementary strategies to prevent SARS-CoV-2 transmission that exert specific pressure on other proteins (e.g., antiviral prophylactics) or that do not exert a specific selective pressure on the virus (e.g., high-efficiency air filtration, masking, ultraviolet air purification) are key to reducing the risk of immune escape. In this context, vaccines that do not provide sterilizing immunity (and therefore continue to permit transmission) will lead to the buildup of large standing populations of virus [47], greatly increasing the risk of immune escape.

3)The evolvability of SARS-CoV-2 in response to selection pressure will determine the ultimate tractability of our efforts at disease control. Our work suggests that the capacity of SARS-CoV-2 to evade the immune system may be greater than originally anticipated and raises the specter of a process of ongoing and continuous evolution in response to antibody-based prophylaxis, occurring on a timescale that may not be convenient or tractable for the design of novel biomedical interventions.

4)Second, the evolutionary pressure on the virus will determine the speed at which resistance to nAbs emerges. The more widely a given epitope is targeted by biomedical intervention, and the more effective it is, the more rapidly it will generate resistance (Fig 4). This is a potential weakness of focusing on only a handful of vaccines (or epitopes) for global deployment.”

5)Finally, our work suggests that immune evasion requiring one to two mutations occurs within months, raising the prospect that this phenomenon will further shorten the duration of natural immunity, which is already limited by the relatively short duration of the humoral [44,45] and cellular [46] responses to SARS-CoV-2 infection.”