We told them this, Vanden Bossche, Yeadon, Alexander, McCullough, Oskoui, Trozzi, Tenenbaum, Risch et al., we did! "Alarming antibody evasion properties of rising SARS-CoV-2 BQ and XBB subvariants"
by Paul Alexander
neutralization of BQ.1, BQ.1.1, XBB, & XBB.1 by sera from vaccinees and infected persons was markedly impaired; Titers against BQ & XBB subvariants were lower by 13-81-fold & 66-155-fold, respectively
It is clear that there is original antigenic sin at play (immune fixation or imprinting to the first prime or exposure), viral immune escape, and thus there will be antibody-dependent enhancement of infection and disease.
Warning, the concern is not only about a highly infectious sub-variant emerging (driven by the sub-optimal mounting immune pressure) and subsequent sub-variants, but a more virulent lethal sub-variant emerging. Yes, this COVID gene therapy can drive the emergence of a lethal sub-variant that could threaten humanity. I have argued that this pandemic will never end for 100 more years once you keep these COVID gene injections going, these sub-optimal non-neutralizing ‘mismatched’ so called ‘vaccines’. IMO, designed to fail, the entire set up, it can never work. Those behind this, the vaccine makers e.g. Bourla and Bancel, CDC, NIH, FDA, Fauci, Francis Collins, Walensky etc. knew and know this vaccine program can never work. You need to ask yourself then, why are they pushing this still when it is clear it has failed. Why the boosters? Are the boosters meant to continue driving re-infections so that emergency powers can remain in place? Is this the grand design?
It is key you understand that the interplay between the infectious pressure of the virus (constant circulating virus) and the immune pressure that the population is putting, the interplay is not understood. This interplay is critical to understand and we are underestimating the evolutionary capacity of the virus to evolve to the immune pressure being placed on it, that is sub-optimal via these COVID gene injections. We have disturbed this balanced viral-host ecosystem. The pandemic is not waning, it is actually expanding with these COVID gene injections. The infectious pressure is remaining extremely high and thus you never ever end this pandemic and will never get to herd immunity if you do not cut the chain of transmission and these COVID gene injections do not stop transmission. Infectious pressure from virus and immune pressure from the mounting population immunity (feeding back onto each other) are critically intertwined and interlinked. One must be reduced. The more pressure we place on the virus, the more susceptible the population becomes for more infection as the vaccinal antibodies are driving increased infectiousness to the vaccinee.
Geert Vanden Bossche constantly calls for the introduction of mass chemoprophylaxis (preventive anti-virals). We will talk on this separately for this is a critical aspect to continue. I am no expert, I stand on the shoulders of the giants McCullough, Risch, Vanden Bossche, Bridle, Yeadon etc.
Once again, if you mass vaccinate across all age-groups into a pandemic with elevated infectious pressure (circulating virus), using a sub-optimal non-sterilizing non-neutralizing vaccine, then you will place the target antigen under pressure (making it uncomfortable) but will not stop infection, replication, or transmission. As a result, the antigen-specific vaccine induced antibodies will bind to the antigen (epitopes) but will not bind optimally and will not neutralize, driving natural selection pressure which will function to ‘select’ for the most infectious ‘fittest’ sub-variants that will become enriched in the environment and become the new ‘dominant’ sub-variant clade. This is what happened as an example with omicron BA 4 and BA 5 and is happening now again with BQ.1.1 and XBB etc. This study is showing you just this.
I know you are fed up just like me of the same story over and over that the sub-variants and in this case BQ.1, BQ.1.1, XBB, and XBB.1 are near completely resistant to the COVID gene injection vaccinal antibodies. I know, I am fed up. The COVID injection has failed complete and anyone taking a shot today including the booster needs their minds checked for sanity!
But I have to keep documenting the science so lawyers globally and scientists globally can take these malevolent Pfizer and Moderna CEOs and CDC and NIH and FDA and Health Canada and PHAC and SAGE etc. officials into court rooms and hopefully jail them in time for this corruption and nefarious malfeasant action, pushing out ineffective and harmful gene injections. That they know do not work, did not work, and will not work. Massively rapid waning immunity with clear rapid negative effectiveness. Even pushing boosters on children when they have statistical zero risk of severe outcome or death from COVID and the injection has failed and is deadly.
So here goes, and I include only the key things to focus on as you add this CELL paper to your library.
Overall, the findings show that the existing circulating subvariants (driven by the mass vaccination in the midst of elevated infectious pressure) reveal no vulnerability (hardly) to neutralization by the sera from vaccinated persons and this is whether they were infected before or not. This is devastating. This included those who were boosted with the new bivalent booster.
•BQ.1, BQ.1.1, XBB, and XBB.1 are the most resistant SARS-CoV-2 variants to date
•Serum neutralization was markedly reduced, including with the bivalent booster
•All clinical monoclonal antibodies were rendered inactive against these variants
•The ACE2 affinity of these variants were similar to their parental strains’
‘The BQ and XBB subvariants of SARS-CoV-2 Omicron are now rapidly expanding, possibly due to altered antibody evasion properties deriving from their additional spike mutations.
…neutralization of BQ.1, BQ.1.1, XBB, and XBB.1 by sera from vaccinees and infected persons was markedly impaired, including sera from individuals boosted with a WA1/BA.5 bivalent mRNA vaccine (this means that the new bivalent booster has failed, it is dead on arrival; do not take it).
…Titers against BQ and XBB subvariants were lower by 13-81-fold and 66-155-fold, respectively, far beyond what had been observed to date.
…Monoclonal antibodies capable of neutralizing the original Omicron variant were largely inactive against these new subvariants, and the responsible individual spike mutations were identified.
…These subvariants were found to have similar ACE2-binding affinities as their predecessors.
…findings indicate that BQ and XBB subvariants present serious threats to current COVID-19 vaccines, render inactive all authorized antibodies, and may have gained dominance in the population because of their advantage in evading antibodies.’
The third embedded figure really shows that regardless of the number of shots and even with the new bivalent booster, the antibody neutralization response is disastrous. Failed!
There are serious catastrophic failures too by the monoclonal antibodies:
‘Lastly, …the spikes of BQ and XBB subvariants have similar binding affinities to hACE2 as the spikes of their predecessors (Figure 5), suggesting that the recently observed growth advantage for these novel subvariants is likely due to some other factors. Foremost may be their extreme antibody evasion properties, especially considering the extensive herd immunity built up in the population over the last three years from infections and vaccinations. BQ.1, BQ.1.1, XBB, and XBB.1 subvariants exhibit far greater antibody resistance than earlier variants, and they may fuel yet another surge of COVID-19 infections.’
‘In fact, combining these results with our prior findings on the serum neutralization of select sarbecoviruses27, there are indications that XBB and XBB.1 are now antigenically more distant than SARS-CoV or some sarbecoviruses in animals (Figure S3). Therefore, it is alarming that these newly emerged subvariants could further compromise the efficacy of current COVID-19 vaccines and result in a surge of breakthrough infections, as well as re-infections.’
These results by Wang et al. matches the findings by Kurhude et al. I prior published in substack:
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