I have written this many times as to the risk of ADEI (and ADED) no doubt schooled by my mentor GVB, McCullough et al. People like Risch, Tenenbaum, my friend Ramin Oskoui (RIP, arguably one of the smartest people I knew). We knew this and saw this would happen, but no, not the idiots at CDC and FDA. Not them, heads too far up their corrupted asses and stealing tax payer grant money studying the mating call of the grass-hopper.
As an example, see this seminal paper by Fantini et al. as it has nuggets for you and hopefully the specious inane vacuous unscientific blockheads at CDC can read it (btw, many there hang on my substacks I am told he he):
What is Fantini saying or trying to say? And back in 2021?
Well, that Antibody dependent enhancement of infection (ADEI when vaccine induced antibodies actually facilitate the vaccinated to become infected) is a real nightmare for vaccine makes and I and we (GVB and McCullough and Oskoui et al.) have argued that this will happen with this set of fraud sub-optimal ineffective COVID mRNA vaccines.
GVB has been stunning in his depth and expertise, easily the giant in immunology and virology globally. He is their father yet they dismiss him. Why? Because the idiots at CDC, NIH, FDA, PHAC, SAGE, past Trump Task Force morons and officials (save Giroir), Biden stupid corrupted health officials like Jha, Walensky et al., cannot and could not read the science, did not understand it like Scott Atlas, did not ‘get’ it and is and were technically incompetent, academically sloppy, and intellectually lazy. That is why we are in the mess we are in. They are morons! Making policy!
For example, Fantini et al.’s study was performed with the ‘original Wuhan/D614G strain. Since the Covid-19 pandemic at that time was dominated with Delta variants, they analyzed the interaction of facilitating antibodies with the NTD (binding site N terminal domain) of those variants.
para…Using molecular modeling approaches, they showed that enhancing antibodies (we may say neutralizing) have a higher affinity for Delta variants than for Wuhan/D614G NTDs. They showed that enhancing antibodies reinforced the binding of the spike trimer to the host cell membrane by clamping the NTD to lipid raft microdomains. This stabilizing mechanism may facilitate the conformational change that induces the demasking of the receptor binding domain.’
As the NTD is also targeted by neutralizing antibodies, our data suggest that the balance between neutralizing and facilitating (we may say non-neutralizing) antibodies in vaccinated individuals is in favor of neutralization for the original Wuhan/D614G strain. What would you call this phenomenon Fantini wrote about?
‘However, in the case of the Delta variant, neutralizing antibodies have a decreased affinity for the spike protein, whereas facilitating antibodies display a strikingly increased affinity.’ Here is the mother load, right here! This my friends is and was ADEI expressed by Fantini et al. in 2021. Blockheads at CDC never read this paper! Only GVB and me and Oskoui and McCullough et al. did. Oskoui discussed this paper with me many times and one by Li et al.
See this paper in 2021 by Li et al. as it too points to ADEI:
‘isolated NAbs against the receptor-binding domain (RBD) or the N-terminal domain (NTD) of SARS-CoV-2 spike from individuals with acute or convalescent SARS-CoV-2 or a history of SARS-CoV infection. Cryo-electron microscopy of RBD and NTD antibodies demonstrated function-specific modes of binding. Select RBD NAbs also demonstrated Fc receptor-γ (FcγR)-mediated enhancement of virus infection in vitro, while five non-neutralizing NTD antibodies mediated FcγR-independent in vitro infection enhancement. However, both types of infection-enhancing antibodies protected from SARS-CoV-2 replication in monkeys and mice.
Three of 46 monkeys infused with enhancing antibodies had higher lung inflammation scores compared to controls. One monkey had alveolar edema and elevated bronchoalveolar lavage inflammatory cytokines. Thus, while in vitro antibody-enhanced infection does not necessarily herald enhanced infection in vivo, increased lung inflammation can rarely occur in SARS-CoV-2 antibody-infused macaques.’
Li et al. is basically saying that infection-enhancing antibodies (thus potentially post virus or vaccine) directed against the N-terminal domain (NTD) of the SARS-CoV-2 spike protein facilitate virus infection in vitro. That is it! ADEI.
What does all of this mean now, August 2023?
It is the continued vaccination of people (especially the inial mass vaccination across all age-groups and not ‘targetted’ vaccination by risk status) while pathogen circulates (massive infectious pressure) using a vaccine that mismatches the dominant variant (e.g. bivalent BA4/BA5 + Wuhan booster while omicron dominated), that is causing continual subvariants to emerge. This will continue for 100 years, as designed by CDC, HHS, FDA, pharma etc. These idiots now want to bring a XBB1.5 updated booster while they morons also say EG.5 and BA 2.86 and FL will like dominate. What do you think will happen? Will there not be viral immune escape? Should we replace the entire CDC with Grade 10 biology students who understand this?
This is CDC today, the morons at CDC, the inept corrupt idiots at CDC:
Based on what CDC knows now, existing tests used to detect and medications used to treat COVID-19 appear to be effective with this variant. BA.2.86 may be more capable of causing infection in people who have previously had COVID-19 or who have received COVID-19 vaccines. Scientists are evaluating the effectiveness of the forthcoming, updated COVID-19 vaccine. CDC’s current assessment is that this updated vaccine will be effective at reducing severe disease and hospitalization. At this point, there is no evidence that this variant is causing more severe illness. That assessment may change as additional scientific data are developed. CDC will share more as we know more.’